Evidence map›Paper›PMID 40873892›Full record

ArticleBrain communications2025

Cerebellum mitochondrial DNA copy number is increased in Parkinson's disease.

Talia Beglarian, David R Tyrpak, J Raphael Gibbs, John Andrew MacKay, Sonja W Scholz, Bryan J Traynor, Marilyn S Albert, Liana S Rosenthal, Ted M Dawson, Juan C Troncoso and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Talia BeglarianDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, 1450 Biggy St. NRT 2502, Los Angeles, CA 90033, USA.ORCID https://orcid.org/0009-0004-2307-3365
David R TyrpakDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, 1450 Biggy St. NRT 2502, Los Angeles, CA 90033, USA.
J Raphael GibbsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
John Andrew MacKayAlfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.ORCID https://orcid.org/0000-0002-3626-1654
Sonja W ScholzNeurodegenerative Diseases Research Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-6623-0429
Bryan J TraynorNeuromuscular Diseases Research Section, National Institute on Aging, Bethesda, MD 20892, USA.
Marilyn S AlbertDepartment of Neurology, Johns Hopkins University Medical Center, Baltimore, MD 21287, USA.
Liana S RosenthalDepartment of Neurology, Johns Hopkins University Medical Center, Baltimore, MD 21287, USA.
Ted M DawsonDepartment of Neurology, Johns Hopkins University Medical Center, Baltimore, MD 21287, USA.ORCID https://orcid.org/0000-0002-6459-0893
Juan C TroncosoDepartment of Neurology, Johns Hopkins University Medical Center, Baltimore, MD 21287, USA.
Dena G HernandezLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Mark R CooksonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-1058-3831
Charles H AdlerDepartment of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.ORCID https://orcid.org/0000-0002-1045-2743
Geidy SerranoBanner Sun Health Research Institute, Sun City, AZ 85351, USA.ORCID https://orcid.org/0000-0002-9527-2011
Andrew B SingletonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Thomas G BeachBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Brooke E HjelmDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, 1450 Biggy St. NRT 2502, Los Angeles, CA 90033, USA.ORCID https://orcid.org/0000-0001-8234-2343

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI JUAN TRONCOSO · 2020 to 2026
$29.3M
Intracellular switching using genetically engineered protein microdomainsR01GM114839 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACKAY, JOHN ANDREW · 2015 to 2019
$1.9M
Novel temperature-responsive fusions of clathrin and caveolin to explore TGF-beta mediated fibrosisF31DK118881 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TYRPAK, DAVID RYAN · 2018 to 2019
$77k
NCI NIH HHS P30 CA014089NIA NIH HHS P30 AG066507NIDDK NIH HHS F31 DK118881NIGMS NIH HHS R01 GM114839
6 · The paper itself

Abstract

Bioinformatics methods can be used to quantify mitochondrial DNA copy number from whole genome sequencing (WGS) data. We evaluated mitochondrial DNA copy number from human brain-derived WGS data using the fastMitoCalc tool. 341 Parkinson's Disease cerebellum samples were compared with 74 age-matched controls from the North American Brain Expression Consortium. Parkinson's Disease cerebellum had significantly higher mitochondrial DNA copy number compared with controls (

Indexed as

cerebellumLewy bodymitochondrial DNA copy numberParkinson’s diseaseWGS

Identifiers

PMID40873892
PMCPMC12378876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.