Trial reportDrug design, development and therapy2025
Effect of Two-Stage Goal-Directed Crystalloid versus Colloid Fluid Therapy on Postoperative Quality of Recovery in Patients Undergoing Laparoscopic Hepatectomy: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
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Abstract
Objective: This study aimed to investigate the impact of two-stage goal-directed crystalloid versus colloid fluid therapy on postoperative quality of recovery in patients undergoing laparoscopic hepatectomy. Patients and Methods: A total of 116 patients scheduled for elective laparoscopic hepatectomy were randomly assigned to two groups: the goal-directed fluid therapy (GDFT) crystalloid group and the GDFT colloid group. Both groups were monitored for stroke volume variation (SVV) using the FloTrac/Vigileo system, and GDFT was guided based on SVV values. Primary outcome was the 24 h postoperative Quality of Recovery-15 (QoR-15) score. Secondary outcome included the estimated blood loss, lactate levels, total fluid infusion volume, hemodynamic status, postoperative nausea and vomiting (PONV) scores, pain scores, postoperative liver and kidney function, and the incidence of postoperative complications. Results: There was no significant difference in the total QoR-15 scores between the two groups at each point in time ( Conclusion: Two-stage goal-directed crystalloid versus colloid fluid therapy had no significant difference in the postoperative quality of recovery in patients undergoing laparoscopic hepatectomy, which is the primary finding of this study. Nevertheless, our data indicated that colloids may reduce postoperative nausea and vomiting (PONV), though this observation requires confirmation in larger-scale trials.
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