Evidence map›Paper›PMID 40873856›Full record

Observational studyDrug design, development and therapy2025

Effects of Different Body Mass Indexes on the Induction Dose of Remimazolam in Patients Undergoing Gynaecological Day Surgery: A Propensity Score-Matched Study.

Hongyi Xiao, Xiuxia Gu, Xinyuan Shi, Shiyu Yu, Ruoyi Ji, Fanceng Ji, Peihe Nie

Abstract readObservational Study
In one paragraph

Observational study in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hongyi XiaoDepartment of Anesthesiology, Weifang People's Hospital, Weifang, 261041, People's Republic of China.ORCID 0000-0002-3534-8731
Xiuxia GuDepartment of Anesthesiology, Weifang People's Hospital, Weifang, 261041, People's Republic of China.
Xinyuan ShiSchool of Anaesthesiology, Shandong Second Medical University, Weifang, 261053, People's Republic of China.ORCID 0009-0006-8542-5682
Shiyu YuSchool of Anaesthesiology, Shandong Second Medical University, Weifang, 261053, People's Republic of China.
Ruoyi JiSchool of Psychology and Cognitive Sciences, Peking University, Beijing, 100871, People's Republic of China.
Fanceng JiDepartment of Anesthesiology, Weifang People's Hospital, Weifang, 261041, People's Republic of China.
Peihe NieDepartment of Anesthesiology, Weifang People's Hospital, Weifang, 261041, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study compared the effects of different body mass indexes (BMI) on the induction dose of remimazolam in patients undergoing gynaecological day surgery, aiming to explore the appropriate weight index of remimazolam for overweight or obese people. Patients and Methods: This was a retrospective, observational study based on propensity score matching (PSM). The patients were divided into two groups according to normal BMI boundaries: group N (BMI<24 kg/m²) and group F (BMI≥24 kg/m²). The primary observation of the study was the anesthetic induction dose per kg of remimazolam calculated on the basis of total body weight (TBW), ideal body weight (IBW), lean body weight (LBW) and corrected body weight (CBW). Results: A total of 250 patients were included in the analysis. After PSM, 94 patients were finally included in each group. The primary observation: there was a significant difference between the two groups in the induction dose per kg of TBW and IBW ( Conclusion: When calculated based on TBW, the induction dose of remimazolam per kilogram (mg/kg) was lower in overweight or obese patients compared to normal-weight patients. For these patients, we recommend using CBW for dose calculation when applying the 0.2-0.4 mg/kg dosing regimen.

Indexed as

Ambulatory Surgical ProceduresBenzodiazepinesBody Mass IndexGynecologic Surgical ProceduresObesityAdultDose-Response Relationship, DrugFemaleHumansMiddle AgedPropensity ScoreRetrospective StudiesBenzodiazepinesremimazolamanesthesiabody mass indexgeneralinduction doseremimazolam

Identifiers

PMID40873856
PMCPMC12379970

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.