SynthesisFrontiers in medicine2025
Bone metastasis and pain research through the dual lens of bibliometrics and bioinformatics: knowledge structure, frontiers, and core pathway analysis (2015-2024).
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Background: Cancer-induced bone pain (CIBP) represents a formidable clinical challenge with complex mechanisms, and existing treatments remain unable to effectively control pain in many patients. This study combined bibliometric and bioinformatic approaches to delineate key research trends, principal themes and future directions in the field of bone metastasis and pain research over the past decade (2015-2024). Methods: We selected 1,822 relevant documents from the Web of Science Core Collection for bibliometric analysis to identify major research characteristics, collaboration networks and emerging trends. Additionally, we employed bioinformatic methods to screen core genes associated with both bone metastasis and cancer pain, and analysed their functions and signalling pathways. Results: Research output and academic influence demonstrated an upward trajectory, with the United States and China being the countries with the highest publication volumes. Research hotspots are shifting from traditional palliative treatments towards precision therapies, with stereotactic body radiotherapy, minimally invasive ablation techniques and neuropathic pain mechanisms representing major research frontiers. Bioinformatic analysis identified core hub genes such as TP53 and EGFR, and revealed significant enrichment of signalling pathways including PI3K-Akt, MAPK and TNF in the common pathological processes of bone metastasis and pain. Conclusion: This study, for the first time combining both methodologies, revealed the field's evolution from traditional treatments towards precision interventions and mechanistic exploration. The molecular targets and signalling pathways we identified provide promising directions for developing novel therapies capable of simultaneously controlling tumour progression and alleviating pain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.