ArticleInfection and drug resistance2025
Clinical Characteristics and Prognosis of Patients with Severe Pneumonia with Neurological Dysfunction: A Regional Multicenter Retrospective Study in Mainland China.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Pneumonia is common in ICU patients with neurological dysfunction, but differences in pulmonary pathogen distribution in this population remain unclear. This study aimed to compare pathogen profiles, clinical features, and outcomes between ICU patients with and without neurological dysfunction. Methods: This regional multicenter retrospective study included adult patients with severe pneumonia admitted to intensive care units (ICUs) in 11 hospitals across Zhejiang and Henan Provinces in mainland China between December 2018 and November 2023. All patients required invasive mechanical ventilation and underwent bronchoalveolar lavage fluid metagenomic next-generation sequencing (mNGS). Patients were classified into neurological dysfunction (ND) and without neurological dysfunction (WND) groups. Clinical characteristics, microbiological findings, and outcomes were compared. Propensity score matching (PSM) and Cox regression were used to assess prognosis. Results: Among 1737 patients, 636 (41.8%) were in the ND group. After PSM, the ND group showed a higher 28-day ICU mortality rate and shorter time to death compared to the WND group. However, ND was not identified as an independent risk factor for 28-day mortality in Cox analysis. The prevalence of Conclusion: ICU patients with neurological dysfunction exhibited distinct pulmonary pathogen profiles and worse outcomes. These findings may inform empirical antimicrobial strategies. Further prospective studies are warranted to validate these results.
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