ArticleFrontiers in pediatrics2025
Auditory evoked potential wave VI as an objective indicator of sedation depth in neonates undergoing chloral hydrate sedation: a double-blind randomized controlled study.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neonatal sedation depth monitoring is critical yet depends on the subjective Ramsay scale when used and lacks objective biomarkers. Although auditory evoked potential (AEP) wave VI disappearance is linked to reduced consciousness, its use for neonatal sedation monitoring remains underexplored. We aimed to determine whether wave VI could function as an objective indicator of sedation levels in neonates. Methods: This prospective, double-blind, randomized trial enrolled 100 neonates requiring hearing screening. Participants were randomly assigned in a 4:1 ratio to either the treatment group ( Results: In the treatment group, wave VI disappearance rates increased in a sedation-dependent manner across the Ramsay Sedation Scale: 0% at level 4, 26% at level 5, and 68.6% at level 6 ( Conclusion: AEP wave VI latency and disappearance are objective, sensitive, and specific indicators of sedation depth in neonates. With further validation, wave VI has the potential to become a reliable neurophysiological tool for precise sedation monitoring in neonates. Clinical Trial Registration: https://www.chictr.org.cn/index.html, identifier ChiCTR2300068407.
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