ArticleFrontiers in psychiatry2025
Dysregulation of G protein subunits in autism: decreased GNAO1 and elevated GNAI1 levels in ASD.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Genomic, Transcriptomic, and Regulomic Analyses Do Not Support Profound Autism as a Distinct Biological Category.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
Objective: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social interaction deficits and repetitive behaviors. This study explores the potential role of G protein subunits GNAO1, GNB1, and GNAI1 in the underlying mechanisms by comparing their serum levels in individuals with ASD and non-autistic participants. Methods: We enrolled 42 children (aged 3-7 years) diagnosed with ASD and 42 age- and sex-matched non-autistic participants. Serum levels of GNAO1, GNB1, and GNAI1 were quantified using ELISA. Additionally, in silico analysis was conducted to investigate protein interaction networks and functional enrichment. Results: Serum GNAO1 levels were significantly decreased ( Conclusions: Our findings suggest that dysregulation of G protein signaling pathways, characterized by reduced GNAO1 and increased GNAI1 levels, may contribute to underlying mechanisms of ASD. Further research is warranted to clarify the mechanistic roles of these subunits in ASD and their potential as biomarkers or therapeutic targets.
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