Evidence map›Paper›PMID 40873628›Full record

ReviewPeerJ2025

Research on the application of biomaterial-based responsive hydrogels in the tumor microenvironment.

Wanrong Yue, Xiaoyu Zhu, Ming Wu, Wenyue Qiang, Yixin Yang, Ziyun Zhang, Youwei Wang, Yuanyin Teng, Mi Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wanrong Yue *Department of Pathology, People's Hospital of Guilin, Guilin, Guangxi, China.
Xiaoyu Zhu *The Third Clinical Medical College, Ningxia Medical College, Yinchuan, Ningxia, China.
Ming WuOrthopedics Department, Gongli Hospital, Shanghai, China.
Wenyue QiangShanghai Jiao Tong University School of Medicine, Shanghai, China.
Yixin YangDepartment of Clinical Medicine, The First Clinical Medical College of Norman Bethune University of Medical Sciences, Changchun, Jilin, China.
Ziyun ZhangSchool of International Education, Hainan Medical University, Haikou, Hainan, China.
Youwei WangBeihua University School of Medicine, Beihua University, Jilin, Jilin, China.
Yuanyin TengInstitute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China.
Mi ZhouDepartment of Orthopedics, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumor microenvironment (TME) is a critical factor influencing the initiation, growth, and spread of solid tumors. Recent advancements highlight biomaterial-based responsive hydrogels as promising smart materials within the TME owing to their high biocompatibility, biodegradability, and sensitivity to various stimuli. This review details the fundamental properties, preparation techniques, and diverse applications of responsive hydrogels, specifically within the TME. Key applications include their use in targeted tumor therapy, controlled drug delivery, and modulation of the complex TME. Recent studies have shown how these hydrogels, by responding to environmental factors such as pH, temperature, or specific biomolecules, can enhance treatment efficacy while minimizing systemic toxicity. Additionally, challenges are identified in terms of hydrogel design, safety, and clinical translation, with future directions aimed at optimizing hydrogel interactions with tumor-specific conditions. This review provides a comprehensive assessment of the current landscape, shedding light on the potential and ongoing research in the field of hydrogel-mediated cancer therapy.

Indexed as

Biocompatible MaterialsHydrogelsNeoplasmsTumor MicroenvironmentAnimalsDrug Delivery SystemsHumansHydrogen-Ion ConcentrationBiocompatible MaterialsHydrogelsBiomaterialsMicroenvironmentResponsive hydrogelsSolid tumorsTumor therapy

Identifiers

PMID40873628
PMCPMC12380388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.