SynthesisFrontiers in cardiovascular medicine2025
Characterization and risk stratification of coronary artery disease in people living with HIV: a global systematic review.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Integrated Model for Evidence-Based Risk Factor Prioritisation and Dynamic Resource Allocation in Hypertension Prevention and Control: A Study Protocol.Healthcare (Basel, Switzerland) · 2026Article
- Risk stratification of hypertension in South Africa: a systematic review with meta-analysis.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Coronary artery disease (CAD) is a leading cause of mortality among people living with HIV (PLWH). Risk stratification remains inconsistent due to geographic disparities, ART-related metabolic effects, and overreliance on strength of association. This review synthesizes global evidence to classify CAD risk factors in PLWH, aiming to improve predictive models and preventative strategies. Methods: Following the PRISMA 2020 guidelines, a systematic review was conducted across six databases: PubMed, Scopus, Web of Science, Medline, CINAHL, and African Journals (SABINET). Two independent reviewers screened studies and extracted data. Narrative synthesis and meta-analysis were conducted. Risk factors were classified using Rw, causality index (CI), and public health priority (PHP). Findings: Twenty-two studies involving 103,370 participants were included. First-class risk factors (CI: 7-10) included hypertension (OR: 4.9; Conclusion: Association strength alone cannot determine CAD risk. Cumulative risk indexing and responsiveness provide a robust framework. Prevention should prioritize hypertension and dyslipidemia management, with interventions for obesity, smoking, and virological failure. Age and hypertension should prompt cardiovascular screening. Standardized risk definitions, accounting for the role of protective factors and integrating evidence with domain knowledge are vital for improved CAD risk stratification and prediction in PLWH. Routine cardiovascular screening in HIV care remains essential. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024524494, PROSPERO CRD42024524494.
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