Evidence map›Paper›PMID 40873605›Full record

Trial reportJournal of biomedical optics2025

Near-infrared light-induced transcranial photobiomodulation enhances the visual pathway's function in healthy volunteers.

Alex O Trofimov, Elizabeth Kalinkina, Anastasia Medvedeva, Ekaterina Volkova, Anastasia Kivenko, Edwin M Nemoto, Olga A Bragina, Denis E Bragin

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07736092 (Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07736092 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled130ConditionsOlder Adults, Surgery, Transcranial Photobiomodulation, Delayed Neurocognitive RecoveryArmsTranscranial photobiomodulation therapy, Transcranial pseudo-photobiomodulation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alex O TrofimovPrivolzhsky Research Medical University, Department of Neurological Diseases, Nizhny Novgorod, Russia.
Elizabeth KalinkinaPrivolzhsky Research Medical University, Department of Neurological Diseases, Nizhny Novgorod, Russia.
Anastasia MedvedevaPrivolzhsky Research Medical University, Department of Neurological Diseases, Nizhny Novgorod, Russia.
Ekaterina VolkovaPrivolzhsky Research Medical University, Department of Neurological Diseases, Nizhny Novgorod, Russia.
Anastasia KivenkoPrivolzhsky Research Medical University, Department of Neurological Diseases, Nizhny Novgorod, Russia.
Edwin M NemotoUniversity of New Mexico, Department of Neurology, School of Medicine, Albuquerque, New Mexico, United States.
Olga A BraginaLovelace Biomedical Research Institute, Albuquerque, New Mexico, United States.
Denis E BraginUniversity of New Mexico, Department of Neurology, School of Medicine, Albuquerque, New Mexico, United States.ORCID https://orcid.org/0000-0003-4894-0061

Funding

Brain Injury Treatment by Modulation of Hemodynamics With Blood Soluble Drag Reducing MoleculesR01NS112808 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2019 to 2023
$2.1M
The mechanisms of cerebral microcirculation response to transcranial stimulation.R21AG089266 · NIA · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI BRAGINA, OLGA A · 2024 to 2024
$597k
NIA NIH HHS R21 AG089266NINDS NIH HHS R01 NS112808
6 · The paper itself

Abstract

Significance: Low-level near-infrared light-induced transcranial photobiomodulation (NIR-TPBM) is a promising technology for improving cerebral blood flow and metabolism. However, the effects of NIR-TPBM on the visual pathway's function remain poorly understood. Aim: The aim was to assess the visual pathway's function changes in response to NIR-TPBM in young, healthy volunteers. Approach: This single-center, randomized, controlled clinical trial included 98 healthy volunteers with a median age of 23.2 years. Participants were randomly assigned to two groups: NIR-TPBM (18 men and 30 women) and sham NIR-TPBM (19 men and 31 women). Eye-tracking procedures were conducted in both groups before and after either PBM or sham intervention. In the NIR-TPBM group, low-fluence NIR-TPBM was applied to the left and right fronto-temporal regions using a NIR-TPBM device (Elmedlife H Results: NIR-TPBM procedures led to a significant increase in both vertical and horizontal VRx values. Post-procedure vertical VRx was significantly higher than pre-procedure values (0.879 [0.761; 0.918] versus 0.774 [0.721; 0.929], Conclusions: NIR-TPBM enhances visual pathways function by increasing both vergence reactivity indices in young healthy volunteers.

Indexed as

Infrared RaysLow-Level Light TherapyVisual PathwaysAdultEye MovementsFemaleHealthy VolunteersHumansMaleYoung Adulteye trackingnear-infrared photobiomodulationvisual pathway’s function

Identifiers

PMID40873605
PMCPMC12380425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.