ArticleToxicological research2025
The systemic toxicity of intravitreally injected gold nanorods in mice: Effects of size, surface conjugation, and post-injection period.
Article in Toxicological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Gold bipyramids as a promising alternative to gold nanorods for analytical and biomedical applications.Beilstein journal of nanotechnology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Gold nanorods (AuNRs) are promising for remote neuronal activation via photothermal effects, but their systemic toxicity when delivered ocularly is unclear. We assessed the systemic safety of intravitreally injected AuNRs in mice over 32 days, testing three formulations: 25-nm diameter Thy-1 conjugated AuNRs (default), 10-nm diameter Thy-1 conjugated AuNRs (effect of size), and 25-nm diameter bare AuNRs (effect of surface chemistry). Thy-1 conjugation aimed to target retinal neurons specifically. Mice received AuNR injections or phosphate-buffered saline as a control. Hematological parameters, serum biochemistry, and body weight were evaluated at 2-, 8-, and 32-days post-injection. Thy-1 conjugated AuNRs did not significantly alter serum biochemical indices or blood counts compared to controls, indicating no systemic toxicity. In contrast, mice injected with bare AuNRs showed a 23% increase in uric acid levels ( Graphical abstract:
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