ArticleNature and science of sleep2025
Sleep Duration and Cardiometabolic-Kidney-Metabolic Syndrome: The Role of Depressive Symptoms in a Longitudinal Study.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Depression and mental health in late adolescents: the sequential mediating roles of quality of life and sleep regularity.BMC psychiatry · 2026Article
- Association of circadian syndrome with the risk of physical, psychological, and cognitive multimorbidities: a prospective cohort study based on the China Health and Retirement Longitudinal Study.Journal of global health · 2025Article
- Associations of afternoon naps with progression of advanced cardiovascular-kidney-metabolic syndrome among Chinese adults aged 45 years and above.Scientific reports · 2025Article
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4 authors.
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Abstract
Background: Sleep disturbances are increasingly recognized as modifiable risk factors for metabolic and cardiovascular diseases. However, the relationship between sleep duration patterns and Cardiometabolic-Kidney-Metabolic (CKM) syndrome remains underexplored, particularly regarding the mediating role of mental health factors. This study investigates the longitudinal association between sleep duration and CKM risk, examining whether depressive symptoms mediate this relationship. Methods: We analyzed data from 6462 participants (aged ≥45 years) from the China Health and Retirement Longitudinal Study. Sleep duration was self-reported and categorized as short (<7 hours), optimal (7-9 hours), or long (>9 hours), with 2-year sleep trajectories also defined. CKM syndrome was classified per American Heart Association guidelines, and depressive symptoms were assessed via the 10-item Center for Epidemiologic Studies Depression Scale. Associations were examined using multivariable logistic regression, restricted cubic splines, and causal mediation analysis. Results: Baseline short sleep duration was independently associated with increased CKM risk (adjusted OR = 1.148; 95% CI: 1.014-1.299). Persistently abnormal sleep over two years further elevated this risk (OR = 1.259; 95% CI: 1.077-1.471). We observed a significant non-linear dose-response relationship between sleep duration and CKM risk (P = 0.031). Causal mediation analysis showed that depressive symptoms partially mediated this association (ACME = -0.002; P < 0.001). Subgroup analyses revealed stronger associations among women, individuals with lower education, and urban residents. Conclusion: Both short and persistently abnormal sleep independently increase CKM syndrome risk, with depressive symptoms acting as a key mediator. These findings highlight the importance of integrated interventions targeting sleep optimization and mental health management, particularly for high-risk demographic subgroups. Sleep assessment should be incorporated into CKM risk stratification and prevention strategies.
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