Evidence map›Paper›PMID 40873460›Full record

Article3 Biotech2025

Functionalized nanoparticles based on β-chitosan and styrene copolymer derivative for donepezil delivery.

Fahima M Helaly, Ahmed A F Soliman, Eman AboBakr Ali

Abstract read
In one paragraph

Article in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fahima M HelalyPolymers and Pigments Department, Chemical Industries Research Institute, National Research Centre (Scopus Affiliation ID 60014618), Dokki, Giza, 12622 Egypt.ORCID 0000-0003-2255-7929
Ahmed A F SolimanDepartment of Pharmacognosy, Pharmaceutical and Drug Industries Institute, National Research Centre (Scopus Affiliation ID 60014618), Dokki, Giza, 12622 Egypt.
Eman AboBakr AliPolymers and Pigments Department, Chemical Industries Research Institute, National Research Centre (Scopus Affiliation ID 60014618), Dokki, Giza, 12622 Egypt.ORCID 0000-0002-3705-6302

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing a drug delivery strategy that can cross the blood-brain barrier is crucial to effective neurological treatment. In this work, a new strategy was introduced for efficient drug delivery of Donepezil based on the preparation of polyelectrolyte complexes (PEC) nanogel from β-chitosan (CS) and the prepared sulfonated styrene-maleic anhydride (S-SMA). First, low-molecular-weight SMA was prepared. Then, sulphonation of SMA was carried out. Three PEC nanoparticles were prepared by mixing three different ratios of S-SMA with β-chitosan. The structure and characteristics of the nanoparticles were thoroughly investigated. Varying S-SMA content (donated CS-S1, CS-S2, and CS-S3) for fixed a β-CS content, the surface charge and average size of the nanoparticles were tunable

Indexed as

Acetyl cholinesterase inhibitoryDonepezil hydrochlorideNanogelSulfonated styrene–maleic anhydrideβ-Chitosan-based polyelectrolyte complex

Identifiers

PMID40873460
PMCPMC12378271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.