ReviewFrontiers in nutrition2025
An overview of basic pathophysiological interactions between gut bacteria and their host.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic analysis of gut microbiome characteristics in Chinese patients with gestational diabetes mellitus.Frontiers in nutrition · 2026Pooled it
- Multi-Dimensional Mechanisms and Druggability Optimization Strategies of Active Ingredients from Traditional Chinese Medicine in the Treatment of Ulcerative Colitis.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Perfluorooctanoic Acid (PFOA) Alters the Structure of the Gut Microbial Community and Colonoid Transcription.Current issues in molecular biology · 2026Article
- Gut microbiome and bile acid metabolism in liver disease: Mechanisms, clinical implications, and therapeutic opportunities.Pharmacological reviews · 2026Review
- Hydrogel-Based Therapeutic Strategies for Post-Cholecystectomy NAFLD: Targeting Bile Acid Signaling, Gut Microbiota, Inflammation, and Hepatic Fibrosis.Gels (Basel, Switzerland) · 2026Review
- The microbiome-gerogene axis: a new frontier in precision geromedicine.Frontiers in aging · 2026Review
- Lung microbiota, gut microbiota, and the lung-gut axis in lung cancer immunotherapy: a tripartite regulatory perspective.Frontiers in immunology · 2026Review
- Gut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Insights into Disease Mechanisms.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sometimes referred to as a "forgotten organ," the gut microbiome (GMB) of humans includes hundreds of commensal bacterial species, which carry several million genes and complement our physiology. Commensal bacteria break down indigestible dietary fiber and provide essential metabolites. These often have a dual action: as "stand-alone" chemicals (e.g., combustibles or emulsifiers) and as signaling molecules that influence host gene expression and physiology. A second function of gut bacteria is to help maintain the intestinal barrier, partly by conditioning the host immune system. Alteration and damage to the GMB have been linked to many pathologies. This review provides an introduction to the more basic mechanisms of GMB-host interaction. It focuses on (a) gut bacteria and their metabolites, and (b) the metabolites' role in host gene regulation and homeostasis. To this end, recent articles were selected, along with some earlier ground-breaking articles. We consider microbiome composition and intestinal homeostasis, microbiome composition and dysbiosis, immune modulation, gut bacteria metabolite chemistry and host gene regulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.