ArticleCurrent drug research reviews2026
Functional Effects of Cromakalim on Aortic Tissue in STZ-Diabetic Rats: Impact of Insulin Treatment.
Article in Current drug research reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The Effect of Chronic Angiotensin (1-7) Treatment on Functional Responses of Isolated Resistance Arteries in Streptozotocin-Induced Diabetic Rats.Fundamental & clinical pharmacology · 2026Article
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Abstract
introductionK
methodsIn this study, the effects of the potassium channel activator cromakalim on aortic function were investigated in streptozotocin (STZ)-diabetic rats at short (1 week), medium (8 weeks), and long-term (14 weeks) durations, including a group treated with insulin for 14 weeks.
resultsCompared with the control group, cromakalim-induced concentration-dependent vasodilation was reduced in the aortas of 8 and 14-week streptozotocin-diabetic rats (p < 0.05). Daily insulin treatment during the long-term (14 weeks) durations normalized the vasodilation response to cromakalim in the aortas of 14-week streptozotocin-diabetic rats. DISCUSSION: Studies with cromakalim on diabetic rat aortic K
conclusionThese findings indicate that potassium channel activity and vascular vasodilation ability decrease in the aortas of streptozotocin-diabetic rats depending on the duration of diabetes. In contrast, potassium channel activity and vascular vasodilation ability return to normal with insulin treatment in 14-week streptozotocin-diabetic aortas.
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