Evidence map›Paper›PMID 40873137›Full record

ArticleRapid communications in mass spectrometry : RCM2025

Molecular Organ Lysate Imprinting: For Precision Recognition and Analysis of Organ-Derived Proteins.

Jatinderpal K Sandhu, Donald J L Jones, Colleen B Maxwell, Charlotte L Gwinnell, Geraldine Williams, Thong Huy Cao, Paulene A Quinn, Leong L Ng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rapid communications in mass spectrometry : RCM, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jatinderpal K SandhuLeicester van Geest MultiOMICs Facility, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-5612-274X
Donald J L JonesLeicester van Geest MultiOMICs Facility, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0001-6583-870X
Colleen B MaxwellLeicester van Geest MultiOMICs Facility, University of Leicester, Leicester, UK.
Charlotte L GwinnellDepartment of Chemistry, George Porter Building University of Leicester, Leicester, UK.
Geraldine WilliamsLeicester van Geest MultiOMICs Facility, University of Leicester, Leicester, UK.
Thong Huy CaoLeicester van Geest MultiOMICs Facility, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-6559-0836
Paulene A QuinnLeicester van Geest MultiOMICs Facility, University of Leicester, Leicester, UK.
Leong L NgLeicester van Geest MultiOMICs Facility, University of Leicester, Leicester, UK.

Funding

John and Lucille van Geest Foundation
6 · The paper itself

Abstract

rationaleMolecular imprinting has emerged as a promising strategy to create custom imprints for precision recognition of proteins. This study proposes using dopamine polymers as a novel approach to enhance the retrieval of proteins from human plasma. Dopamine polymers possess adhesive properties due to their ability to form hydrophobic interactions, π-π, hydrogen bonding and van der Waals forces with various substrates; in this study, we have leveraged these adhesive properties to capture and retrieve proteins from complex biological samples.

methodsWe imprinted proteins derived from mouse heart lysate and evaluated the performance of the resulting molecularly imprinted polymer for retrieval of the human protein cardiovascular disease plasma samples.

resultsOur results demonstrated the retrieval of troponin T, fatty acid-binding protein, creatine kinase, lactate dehydrogenase, and myosin-binding protein C. This novel application of dopamine polymers in protein enrichment and analysis facilitates the discovery of novel biomarkers from complex matrices, such as plasma, and promotes deeper insights into complex biological processes.

conclusionsThis method, characterized by high specificity and stability, offers a new approach for the detection of low abundant proteins and provides a scientific basis for the future development of new diagnostic tools and personalized medical strategies.

Indexed as

Blood ProteinsMolecular ImprintingMolecularly Imprinted PolymersAnimalsDopamineHumansMiceMyocardiumBlood ProteinsDopamineMolecularly Imprinted Polymersaffinity ligandsdopamine polymersmass spectrometrymolecular imprintingorgan lysate imprintingplasma proteomicsprotein captureprotein retrievaltargeted proteomics

Identifiers

PMID40873137
PMCPMC12391850

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.