ArticleAlcohol, clinical & experimental research2025
Altered neuronal network connectivity in children with fetal alcohol spectrum disorder and its association with inhibitory function.
Article in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Developmental Neurotoxicity of Alcohol from Neuronal Basis to Behavioural Outcomes: A Comprehensive Review.Neurology international · 2026Review
- Subtle Cognitive Variability in Foetal Alcohol Syndrome Spectrum: Intelligence Profiles and Verbal Fluency Performance Across Diagnostic Categories in Polish Population.Journal of clinical medicine · 2026Article
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Authors and funding
5 authors.
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Abstract
backgroundFetal alcohol spectrum disorder (FASD) is associated with widespread neurocognitive deficits, including impairments in executive function, attention, and inhibitory control. However, understanding of the neural mechanisms underlying these deficits in young children 6-8 years of age remains limited. This study investigated functional connectivity (FC) alterations in key brain networks related to inhibitory control and executive function in children with FASD compared to typically developing controls (TDC).
methodsSeed-based connectivity (SBC) analysis was conducted in 27 children with FASD and 30 TDC, focusing on the medial prefrontal cortex (MPFC) within the Default Mode Network (DMN) and Frontal Parietal Network (FPN). FC differences were assessed across resting-state conditions (eyes closed vs. eyes open) and correlated with Conners Continuous Performance Test (CPT).
resultsChildren with FASD exhibited significantly reduced FC between MPFC and limbic regions, including the amygdala, hippocampus, and brainstem, suggesting impairments in emotion regulation and cognitive control. The FPN showed altered connectivity with the middle temporal gyrus and inferior lateral occipital cortex, regions crucial for higher order cognitive processing. Significant interactions between groups and resting-state condition were observed, with altered connectivity patterns in the MPFC and FPN suggesting sensory-motor and cognitive control disruptions. FC patterns in these networks were significantly correlated with CPT performance, including increased errors of omission and reaction time variability, indicating deficits in sustained attention and response inhibition.
conclusionOur findings reveal early disruptions in FC within the DMN and FPN in young children with FASD, highlighting altered interactions between key brain regions implicated in inhibitory control and executive function. These neural alterations were associated with behavioral deficits in attention and cognitive control, suggesting that FC abnormalities may underlie core cognitive impairments in FASD. Findings underscore the importance of early identification and intervention strategies targeting neural network dysfunctions to improve cognitive outcomes in children with FASD.
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