Evidence map›Paper›PMID 40873008›Full record

ArticleAutophagy2026

Autophagy dictates PHGDH-mediated serine metabolism in a timely manner to support oocyte development.

Hainan He, Qianqian Zhang, Zhengang Fan, Hongfei Duan, Yu Wang, Bingbing Luo, Qiao Li, Junjie Liu, Delong Li, Shengya Fang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hainan HeInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Qianqian ZhangInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Zhengang FanInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Hongfei DuanInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Yu WangInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Bingbing LuoHubei Hongshan Laboratory, Wuhan, P.R. China.
Qiao LiInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Junjie LiuInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Delong LiInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Shengya FangInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Xia ZhangInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Junling WangHuangshi Key Laboratory of Assisted Reproduction and Reproductive Medicine, Huangshi Central Hospital, Huangshi, P. R. China.
Yi-Liang MiaoInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.
Jilong ZhouInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The metabolic co-dependence of the oocyte and surrounding granulosa cells is crucial for oocyte developmental competence. Previous research has shown that serine-glycine and its key downstream metabolites are significantly involved in the process of oocyte maturation. However, the mechanism of serine metabolism and its influence on oocyte maturation remain unclear. In this study, we demonstrate that the serine metabolism enzyme PHGDH, which mediates

Indexed as

AutophagyOocytesOogenesisPhosphoglycerate DehydrogenaseSerineAnimalsFemaleGranulosa CellsInsulin-Like Growth Factor IMiceS-AdenosylmethionineInsulin-Like Growth Factor IPhosphoglycerate DehydrogenaseS-AdenosylmethionineSerineCALCOCO2/NDP52de novo serine synthesisgranulosa cell homeostasisoocyte maturationPHGDHselective degradation

Identifiers

PMID40873008
PMCPMC12758286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.