Evidence map›Paper›PMID 40872887›Full record

ArticleVaccines2025

Poxvirus K3 Orthologs Regulate NF-κB-Dependent Inflammatory Responses by Targeting the PKR-eIF2α Axis in Multiple Species.

Huibin Yu, Mary Eloise L Fernandez, Chen Peng, Dewi Megawati, Greg Brennan, Loubna Tazi, Stefan Rothenburg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huibin YuDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95618, USA.ORCID 0000-0002-2430-272X
Mary Eloise L FernandezDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95618, USA.ORCID 0009-0007-1643-3432
Chen PengKey Laboratory of Animal Epidemiology and Zoonosis, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Dewi MegawatiDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95618, USA.ORCID 0000-0001-9230-2265
Greg BrennanDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95618, USA.ORCID 0000-0002-4339-9045
Loubna TaziDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95618, USA.ORCID 0000-0003-1300-0010
Stefan RothenburgDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95618, USA.ORCID 0000-0002-2525-8230

Funding

Importance of Species-Specific Interactions of PKR with Poxvirus Inhibitors for Virus Replication and Host RangeR01AI114851 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ROTHENBURG, STEFAN · 2015 to 2019
$1.8M
NIAID NIH HHS R01 AI114851NIH HHS 1R01AI114851-15
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ATF4eIF2inflammatory responsesK3 orthologsmyxoma virusNF-κBphosphorylationPKRpoxviruses

Identifiers

PMID40872887
PMCPMC12390001

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.