Evidence map›Paper›PMID 40872879›Full record

ArticleVaccines2025

Safety and Toxicology Profile of TT-6-AmHap Heroin Conjugate Vaccine.

Essie Komla, Erwin G Abucayon, C Steven Godin, Agnieszka Sulima, Arthur E Jacobson, Kenner C Rice, Gary R Matyas

Abstract read
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Essie KomlaLaboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Center for Military Infectious Diseases Research, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Erwin G AbucayonLaboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Center for Military Infectious Diseases Research, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
C Steven GodinInotiv, 13 Firstfield Rd., Suite 110, Gaithersburg, MD 20878, USA.
Agnieszka SulimaDrug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0002-8849-9736
Arthur E JacobsonDrug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0002-0011-8354
Kenner C RiceDrug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892, USA.
Gary R MatyasLaboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Center for Military Infectious Diseases Research, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.ORCID 0000-0002-2074-2373

Funding

INTERACT Meeting with FDA on Cohort Design and Development of ALFQ as an Adjuvant for Heroin VaccineUG3DA048351 · NIDA · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI MATYAS, GARY R. · 2018 to 2019
$8.2M
Development of a Practical Heroin-HIV VaccineDP1DA034787 · NIDA · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI MATYAS, GARY R. · 2012 to 2016
$7.2M
NIDA NIH HHS DP1 DA034787NIDA NIH HHS UG3 DA048351NIH National Institute on Drug Abuse 1DP1DA034787-01NIH National Institute on Drug Abuse UG3DA048351U.S. Department of Defense W81XWH-07-2-067
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adjuvantsconjugate vaccineheroin vaccineopioidopioid use disorderrabbitssafetytoxicityvaccine efficacy

Identifiers

PMID40872879
PMCPMC12390132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.