Evidence map›Paper›PMID 40872861›Full record

ArticleViruses2025

"Big Events" and HIV Transmission Dynamics: Estimating Time Since HIV Infection from Deep Sequencing Data Among Sex Workers and Their Clients in Dnipro, Ukraine.

François Cholette, Nicole Herpai, Leigh M McClarty, Olga Balakireva, Daryna Pavlova, Anna Lopatenko, Rupert Capiña, Paul Sandstrom, Michael Pickles, Evelyn Forget and 3 more

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Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

François CholetteNational Sexually Transmitted and Blood-Borne Infection Laboratory, National Microbiology Laboratory at the J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, 745 Logan Avenue, Winnipeg, MB R3E 3L5, Canada.ORCID 0000-0001-8706-8128
Nicole HerpaiCollege of Community and Global Health, University of Manitoba, Winnipeg, MB R3E 0W3, Canada.ORCID 0000-0002-7561-0589
Leigh M McClartyCollege of Community and Global Health, University of Manitoba, Winnipeg, MB R3E 0W3, Canada.ORCID 0000-0003-0183-2768
Olga BalakirevaInstitute for Economics and Forecasting, Ukrainian National Academy of Sciences, 01011 Kyiv, Ukraine.
Daryna PavlovaUkrainian Institute for Social Research after Oleksandr Yaremenko, 01011 Kyiv, Ukraine.ORCID 0000-0003-1461-9616
Anna LopatenkoDnipropetrovsk Oblast Medical Centre of Socially Significant Diseases, 49051 Dnipro, Ukraine.
Rupert CapiñaNational Sexually Transmitted and Blood-Borne Infection Laboratory, National Microbiology Laboratory at the J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, 745 Logan Avenue, Winnipeg, MB R3E 3L5, Canada.
Paul SandstromNational Sexually Transmitted and Blood-Borne Infection Laboratory, National Microbiology Laboratory at the J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, 745 Logan Avenue, Winnipeg, MB R3E 3L5, Canada.
Michael PicklesMedical Research Council Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London W12 0BZ, UK.
Evelyn ForgetCollege of Community and Global Health, University of Manitoba, Winnipeg, MB R3E 0W3, Canada.
Sharmistha MishraMAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1A6, Canada.ORCID 0000-0001-8492-5470
Marissa L BeckerDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
On Behalf Of The Dynamics Study Team

Funding

Canadian Institutes for Health Research PJT-148876
6 · The paper itself

Abstract

backgroundMajor geopolitical events and structural shocks are thought to play a significant role in shaping HIV epidemics by influencing individual behaviours, reshaping social networks, and impacting HIV prevention and treatment programs. Here, we describe individual-level measures of estimated time since HIV infection (ETI) from viral next-generation sequencing data among female sex workers and their clients in relation to significant geopolitical events in Ukraine.

methodsThe Dynamics Study is a cross-sectional integrated biological and behavioural survey conducted among female sex workers and their clients in Dnipro, Ukraine (December 2017 to March 2018). We were able to successfully sequence a portion of the HIV

resultsThe median ETIs for female sex workers and their clients were 5.4 years (IQR = 2.9, 6.6) and 6.5 years (IQR = 5.4, 10.8), respectively. Nearly all HIV acquisition events (

conclusionOur findings suggest that most HIV acquisition in this small subset of female sex workers and clients living with HIV occurred during periods of economic decline. Molecular studies on timing of HIV acquisition against timing of major geopolitical events offer a novel way to contextualize how such events may shape transmission patterns.

Indexed as

HIV InfectionsSex WorkersAdultCross-Sectional StudiesDrug Resistance, ViralFemaleGenotypeHigh-Throughput Nucleotide SequencingHIV-1HumansMiddle AgedTime FactorsUkraineYoung Adultconflicthuman immunodeficiency virusintegrated biological and behavioural surveillancekey populationssex work

Identifiers

PMID40872861
PMCPMC12390718

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LicenceCC BY
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