Evidence map›Paper›PMID 40872831›Full record

ArticleViruses2025

First Use of Phage Therapy in Canada for the Treatment of a Life-Threatening, Multidrug-Resistant

Melissa T Cammuso, Bradley W M Cook, D William Cameron, Stephen Ryan, Marielou Tamayo, Melissa J Peters, Tia Arnaud, Stephanie Lau, Henrik Almblad, Nicolas Fournier and 8 more

Abstract readCase Reports
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Successful use of bacteriophage therapy for aJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2026
    Article
  3. The Evolution of Symbiosis inBiomolecules · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Melissa T CammusoDepartment of Pharmacy, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Bradley W M CookCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.ORCID 0000-0002-8042-5660
D William CameronDivision of Infectious Diseases, Department of Medicine, University of Ottawa at The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0002-0090-3539
Stephen RyanDepartment of Medical Imaging, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Marielou TamayoCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.
Melissa J PetersCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.ORCID 0000-0002-0232-6667
Tia ArnaudCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.
Stephanie LauCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.
Henrik AlmbladCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.ORCID 0000-0002-2010-3264
Nicolas FournierCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.
Karen LoVetriCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.
Tasia J LightlyCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.
Yuen Ming ChungCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.
Riya RoyCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.
Natasha TheriaultCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.
Steven S TheriaultCytophage Technologies, Ltd., Oak Bluff, MB R4G 0B1, Canada.
Gina A SuhDivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-7434-6897
Marisa A AzadDivision of Infectious Diseases, Department of Medicine, University of Ottawa at The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0002-5454-3591

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the first use of phage therapy in Canada for the treatment of a life-threatening periprosthetic joint infection (PJI), with successful outcome. PJI is a devastating complication of joint replacement surgery, with high morbidity and mortality. Our patient presented with early sepsis from a chronic recalcitrant multidrug-resistant (MDR)

Indexed as

Phage TherapyProsthesis-Related InfectionsStaphylococcal InfectionsStaphylococcus epidermidisAgedAnti-Bacterial AgentsBacteriophagesCanadaDrug Resistance, Multiple, BacterialFemaleHumansTreatment OutcomeAnti-Bacterial Agentsantibiotic resistanceperiprosthetic joint infectionphage therapy

Identifiers

PMID40872831
PMCPMC12390693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.