Evidence map›Paper›PMID 40872781›Full record

ArticleViruses2025

Chimeric Vesicular Stomatitis Virus Bearing Western Equine Encephalitis Virus Envelope Proteins E2-E1 Is a Suitable Surrogate for Western Equine Encephalitis Virus in a Plaque Reduction Neutralization Test.

Kerri L Miazgowicz, Bailey E Maloney, Melinda A Brindley, Mattie Cassaday, Raegan J Petch, Paul Bates, Aaron C Brault, Amanda E Calvert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kerri L MiazgowiczArboviral Diseases Branch, Division of Vector-Borne Diseases, U.S. Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA.
Bailey E MaloneyArboviral Diseases Branch, Division of Vector-Borne Diseases, U.S. Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA.ORCID 0000-0002-5509-2542
Melinda A BrindleyDepartment of Infectious Diseases, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-4929-8085
Mattie CassadayArboviral Diseases Branch, Division of Vector-Borne Diseases, U.S. Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA.ORCID 0009-0002-0920-7254
Raegan J PetchDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-4508-4362
Paul BatesDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-3918-5976
Aaron C BraultArboviral Diseases Branch, Division of Vector-Borne Diseases, U.S. Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA.ORCID 0000-0001-5801-3021
Amanda E CalvertArboviral Diseases Branch, Division of Vector-Borne Diseases, U.S. Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA.ORCID 0000-0002-8237-2654

Funding

VMD-PhD Training in Infectious Disease-Related ResearchT32AI070077 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michael Lee Atchison · 2008 to 2026
$3.5M
Development of vaccines targeting a tick-borne phlebovirusR01AI152236 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BATES, PAUL · 2020 to 2024
$3.0M
NIAID NIH HHS R01 AI152236NIAID NIH HHS T32 AI070077
6 · The paper itself

Abstract

In December 2023, infections of western equine encephalitis virus (WEEV) within Argentina were reported to the World Health Organization (WHO). By April 2024, more than 250 human infections, 12 of which were fatal, and 2500 equine infections were identified in South America. Laboratory diagnosis and surveillance in affected countries were hindered by a lack of facilities equipped with BSL-3 laboratories, as confirmatory serodiagnosis for WEEV requires live virus in the plaque reduction neutralization test (PRNT). To expand serodiagnosis for WEEV in the Americas, we developed a virus chimera composed of vesicular stomatitis virus (VSV) engineered to display the E2-E1 glycoproteins of WEEV (VSV/WEEV) in place of the VSV glycoprotein (G). PRNT

Indexed as

Encephalitis Virus, Western EquineEncephalomyelitis, EquineNeutralization TestsVesicular stomatitis Indiana virusVesiculovirusViral Envelope ProteinsAnimalsAntibodies, NeutralizingAntibodies, ViralCell LineChickensChimeraHorse DiseasesHorsesHumansMiceAntibodies, NeutralizingAntibodies, ViralViral Envelope Proteinsalphavirusdiagnosticsmosquito-borne virusesplaque reduction neutralization testserologyvesicular stomatitis virus chimerawestern equine encephalitis

Identifiers

PMID40872781
PMCPMC12390645

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.