Evidence map›Paper›PMID 40872728›Full record

ReviewVeterinary sciences2025

A Comprehensive Review: Bovine Respiratory Disease, Current Insights into Epidemiology, Diagnostic Challenges, and Vaccination.

Stephanie O'Donoghue, Sinéad M Waters, Derek W Morris, Bernadette Earley

Abstract readReview
In one paragraph

Review in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Animals : an open access journal from MDPI · 2026
    Review
  3. Article
  4. Article
  5. Potential Host-Directed Mechanisms ofVeterinary sciences · 2026
    Article
  6. Article
  7. Review
  8. Exploring clonality ofMicrobiology spectrum · 2026
    Article
  9. Genomic diversity and virulence ofMicrobial genomics · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stephanie O'DonoghueAnimal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre (AGRIC), Teagasc, Grange, Dunsany, C15 PW93 Co. Meath, Ireland.
Sinéad M WatersSchool of Biological and Chemical Sciences, University of Galway, H91 TK33 Galway, Ireland.
Derek W MorrisSchool of Biological and Chemical Sciences, University of Galway, H91 TK33 Galway, Ireland.ORCID 0000-0002-3413-570X
Bernadette EarleyAnimal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre (AGRIC), Teagasc, Grange, Dunsany, C15 PW93 Co. Meath, Ireland.ORCID 0000-0002-9772-2813

Funding

Department of Agriculture, Food and the Marine (DAFM) US-Ireland R&D partnership call (Project 16/RD/US-ROI/11), the US- Ireland Tri Partite Grant (2018US-IRL200), and the European Union Horizons 2020, HoloRuminant project (Grant agreement No. 101000213). Project 16/RD/US-ROI/11; 2018US-IRL200; Grant agreement No. 101000213
6 · The paper itself

Abstract

The aim of this comprehensive review is to synthesize current knowledge on bovine respiratory disease (BRD), enhance diagnostic strategies, and support effective prevention and management practises. BRD remains a leading cause of morbidity and mortality in cattle, driven by a complex interplay of viral and bacterial pathogens, host factors, environmental stressors, and management conditions. Its prevalence (2.1% to 20.2%) varies across geographical regions, age groups, and diagnostic methods. BRD leads to significant economic losses through direct impacts such as mortality, reduced growth rates, and lighter carcass weights, as well as indirect costs like market restrictions and long-term productivity declines. Diagnosing BRD is challenging due to its non-specific clinical signs and frequent subclinical presentations. Traditional diagnostic tools like clinical respiratory scoring (CRS) systems provide structure but suffer from low sensitivity and subjectivity. Behavioural monitoring shows promise by detecting early changes in feeding, movement, and social behaviours. Thoracic auscultation is widely used but limited in accuracy. Thoracic ultrasonography (TUS) stands out as a more sensitive method for detecting subclinical disease and correlating with growth outcomes. Combining CRS with TUS enhances early and accurate detection. Advancing diagnostic approaches is critical for improving animal health and minimizing economic losses in cattle production systems.

Indexed as

bacterial pathogensbehaviourbovine respiratory disease (BRD)clinical respiratory scoresdiagnosisthoracic ultrasonography (TUS)vaccinationviral pathogens

Identifiers

PMID40872728
PMCPMC12390213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.