Evidence map›Paper›PMID 40872679›Full record

ArticleVeterinary sciences2025

Congenital Malformations of the Central Nervous System Caused by Bluetongue Virus Serotype 3 (BTV-3) in Two Calves.

Phuong Do Duc, Solveig Reeh, Pauline Pöpperl, Tom Schreiner, Natascha Gundling, Andreas Beineke, Peter Wohlsein, Martina Hoedemaker

Abstract readCase Reports
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Phuong Do DucClinic for Cattle, University of Veterinary Medicine Foundation, 30173 Hannover, Germany.
Solveig ReehClinic for Small Animals, University of Veterinary Medicine Foundation, 30559 Hannover, Germany.
Pauline PöpperlDepartment of Pathology, University of Veterinary Medicine Foundation, 30559 Hannover, Germany.
Tom SchreinerDepartment of Pathology, University of Veterinary Medicine Foundation, 30559 Hannover, Germany.ORCID 0000-0002-0978-2067
Natascha GundlingClinic for Cattle, University of Veterinary Medicine Foundation, 30173 Hannover, Germany.ORCID 0000-0002-4510-3922
Andreas BeinekeDepartment of Pathology, University of Veterinary Medicine Foundation, 30559 Hannover, Germany.
Peter WohlseinDepartment of Pathology, University of Veterinary Medicine Foundation, 30559 Hannover, Germany.ORCID 0000-0001-9184-4134
Martina HoedemakerClinic for Cattle, University of Veterinary Medicine Foundation, 30173 Hannover, Germany.ORCID 0000-0001-8154-2642

Funding

This research was funded by the Open Access Publication Fund of the University of Veterinary Medicine Hannover, Foundation
6 · The paper itself

Abstract

Since the first emergence of the Bluetongue virus (BTV) in 2006 in Northern Europe, there has been a reported association between BTV Serotype 8 (BTV-8) and brain malformations in calves. The first BTV-3 outbreak in Germany was registered in October 2023. Since then, numbers have increased steadily. In a suckler cow herd in the Lower Saxony region, two Angus calves with clinical signs of diffuse encephalopathy, including ataxia, abnormal gait, and central blindness, were born in autumn 2024. Both calves were submitted for Magnetic Resonance Imaging (MRI) and pathological examination, revealing hydranencephaly and internal hydrocephalus, respectively. BTV-3 was detected in blood and tissue samples of both calves using BTV-specific real-time PCR. The presented findings demonstrate that there seems to be an association between transplacental BTV-3 infections and congenital malformations in calves, as previously reported for BTV-8 and -10.

Indexed as

bluetongue virus serotype 3calfcongenitalGermanymalformation

Identifiers

PMID40872679
PMCPMC12389954

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.