Evidence map›Paper›PMID 40872652›Full record

ReviewVeterinary sciences2025

Research Progress on the Gc Proteins of Akabane Virus.

Xiaolin Lan, Fang Liang, Gan Li, Weili Kong, Ruining Wang, Lin Wang, Mengmeng Zhao, Keshan Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Genetic evolution analysis of AKAV Gc gene.Frontiers in veterinary science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaolin LanProvincial Key Laboratory of Animal, Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.
Fang LiangProvincial Key Laboratory of Animal, Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.
Gan LiProvincial Key Laboratory of Animal, Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.
Weili KongGladstone Institutes of Virology and Immunology, University of California, San Francisco, CA 94158, USA.
Ruining WangCollege of Veterinary. Medicine, Henan University of Animal Husbandry and Economy; Zhengzhou 450046, China.
Lin WangInstitute of Cancer Sciences, University of Glasgow, Glasgow G12 80QQ, UK.
Mengmeng ZhaoProvincial Key Laboratory of Animal, Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.ORCID 0000-0003-4143-3606
Keshan ZhangProvincial Key Laboratory of Animal, Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528225, China.

Funding

Guangdong Provincial Department of Education's distinctive innovation in-itiative 2023KTSCX128the National Natural Science Foundation of China 31902279
6 · The paper itself

Abstract

The Akabane virus (AKAV) is a significant member of the Orthobunyavirus genus, with its envelope glycoprotein Gc, focusing on its molecular structural features, immunoregulatory mechanisms, and application value in pathogen diagnosis and vaccine design. As a key structural protein of AKAV, Gc mediates virus adsorption and neutralizing antibody recognition through the N-terminal highly variable region (HVR), while the C-terminal conserved region (CR) dominates the membrane fusion process, and its glycosylation modification has a significant regulatory effect on protein function. In clinical diagnostics, serological assays based on Gc proteins (e.g., ELISA, immunochromatographic test strips) have been standardized; in vaccine development, the neutralizing epitope of Gc proteins has become a core target for subunit vaccine design. Follow-up studies were deeply needed to analyze the structure-function interaction mechanism of Gc proteins to provide theoretical support for the construction of a new type of AKAV prevention and control system.

Indexed as

Akabane disease virusGc proteinOrthobunyavirusthe Simbu serogroup viruses

Identifiers

PMID40872652
PMCPMC12390303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.