Evidence map›Paper›PMID 40872625›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Identification of Potential Pteridin Reductase-1 Inhibitors for the Treatment of Leishmaniasis: A Bioinformatics Approach.

Paulo R da S R Júnior, Lúcio R de Lima, Luciane B Silva, Ryan S Ramos, Vitor H da S Sanches, Njogu M Kimani, Gustavo H G Trossini, Joaquín M Campos, Cleison C Lobato, Cleydson B R Santos

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paulo R da S R JúniorGraduate Program in Pharmaceutical Sciences, Federal University of Amapá, Macapá 68902-280, AP, Brazil.
Lúcio R de LimaLaboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, AP, Brazil.
Luciane B SilvaLaboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, AP, Brazil.
Ryan S RamosLaboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, AP, Brazil.ORCID 0000-0003-1802-1320
Vitor H da S SanchesLaboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, AP, Brazil.
Njogu M KimaniNatural Product Chemistry and Computational Drug Discovery Laboratory, Department of Physical Sciences, University of Embu, Embu P.O. Box 6-60100, Kenya.ORCID 0000-0002-5171-1940
Gustavo H G TrossiniLaboratory of Integration Techniques Experimental and Computational in Drug Design, Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, SP, Brazil.ORCID 0000-0003-3634-2531
Joaquín M CamposDepartment of Pharmaceutical and Organic Chemistry, Faculty of Pharmacy, Campus of Cartuja, University of Granada, 18071 Granada, Spain.ORCID 0000-0002-9035-8123
Cleison C LobatoGraduate Program in Pharmaceutical Sciences, Federal University of Amapá, Macapá 68902-280, AP, Brazil.ORCID 0000-0003-2213-239X
Cleydson B R SantosGraduate Program in Pharmaceutical Sciences, Federal University of Amapá, Macapá 68902-280, AP, Brazil.ORCID 0000-0002-0271-335X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leishmania majormethotrexatemolecular dockingpteridine reductase-1virtual screening

Identifiers

PMID40872625
PMCPMC12389166

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.