Evidence map›Paper›PMID 40872605›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Unlocking Therapeutic Potential of Novel Thieno-Oxazepine Hybrids as Multi-Target Inhibitors of AChE/BChE and Evaluation Against Alzheimer's Disease: In Vivo, In Vitro, Histopathological, and Docking Studies.

Khulood H Oudah, Mazin A A Najm, Triveena M Ramsis, Maha A Ebrahim, Nirvana A Gohar, Karema Abu-Elfotuh, Ehsan Khedre Mohamed, Ahmed M E Hamdan, Amira M Hamdan, Reema Almotairi and 4 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Khulood H OudahDepartment of Pharmacy, Mazaya University College, Nasiriyah 64001, Iraq.ORCID 0000-0002-5014-7129
Mazin A A NajmDepartment of Pharmacy, Mazaya University College, Nasiriyah 64001, Iraq.
Triveena M RamsisDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Kantara Branch, Ismailia 41636, Egypt.ORCID 0000-0003-2485-5479
Maha A EbrahimDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.ORCID 0000-0001-5877-0671
Nirvana A GoharDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo 11571, Egypt.ORCID 0000-0002-6442-7762
Karema Abu-ElfotuhDepartment of Clinical Pharmacy, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.
Ehsan Khedre MohamedDepartment of Biochemistry, Egyptian Drug Authority (EDA), Formerly National Organization of Drug Control and Research (NODCAR), Giza 12654, Egypt.ORCID 0000-0003-4956-1522
Ahmed M E HamdanDepartment of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0003-4930-792X
Amira M HamdanOceanography Department, Faculty of Science, Alexandria University, Alexandria 21515, Egypt.
Reema AlmotairiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-1432-460X
Shaimaa R AbdelmohsenDepartment of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, Cairo 11754, Egypt.ORCID 0000-0002-9825-0694
Khaled Ragab AbdelhakimDepartment of Histology, Misr University for Science and Technology, Giza 12566, Egypt.
Abdou Mohammed Ahmed ElsharkawyAnatomy Department, Faculty of Medicine, Al-Azhar University, Cairo 11754, Egypt.ORCID 0000-0002-9304-5309
Eman A FayedDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.ORCID 0000-0002-4579-5180

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AChEanti-inflammatory biomarkersantioxidant biomarkersBChEbicyclicCNSdocking studieshistopathological examinationin silico ADMETmulti-targettricyclic

Identifiers

PMID40872605
PMCPMC12389534

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.