ArticleMicromachines2025
A Microfluidic Approach for Assessing the Rheological Properties of Healthy Versus Thalassemic Red Blood Cells.
Article in Micromachines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Review
- On-Chip Evaluation of Red Blood Cell Deformability Through Transit Velocity Index in Hematological Diseases.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Comparative Evaluation of Two Image-Analysis Software Platforms for Microfluidic Assessment of Red Blood Cell Deformability in Chronic Lymphocytic Leukemia.Micromachines · 2026Article
- Micro Blood Flow-Resolved Rheometry.Micromachines · 2026Article
- Editorial for the Special Issue on the Application of Microfluidic Technology in Bioengineering.Micromachines · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The deformability of red blood cells (RBCs) is critical for microvascular circulation and is impaired in hematological disorders such as thalassemia, a prevalent public health concern in Guangdong, China. While microfluidics enable high-precision deformability assessment, current studies lack standardization in deformation metrics and rarely investigate post-deformation recovery dynamics. This study introduces an automated microfluidic platform for systematically evaluating RBC deformability in healthy and thalassemic individuals. A biomimetic chip featuring 4 µm, 8 µm, and 16 µm wide channels (7 µm in height) was designed to simulate capillary dimensions, with COMSOL CFD numerical modeling validating shear stress profiles. RBC suspensions (10
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Registered trials
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