Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
22 authors.
Nágila Rocha AguilarLaboratório de Pesquisa em Virologia Animal, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0002-5538-1934
Beatriz Senra Alvares da Silva SantosLaboratório de Pesquisa em Virologia Animal, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0002-1497-4397
Bruno Zinato CarraroIntegrall Soluções em Produção Animal, Patos de Minas 38700-052, Brazil.
Brenda Monique Magalhães RochaLaboratório de Pesquisa em Virologia Animal, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Jardelina de Souza Todao BernardinoCentro para Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, São Paulo 05503-900, Brazil.
Ana Luiza Soares FraihaLaboratório de Pesquisa em Virologia Animal, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0003-2100-8696
Alex Ranieri Jeronimo LimaCentro para Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0002-5283-7502
Gabriela RibeiroCentro para Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, São Paulo 05503-900, Brazil.
Alessandra Silva DiasUSDA-ARS-National Animal Disease Center Ames, 1920 Dayton Ave, Ames, IA 50010, USA.ORCID 0000-0003-4545-6530
Renata Rezende CarvalhoLaboratório de Pesquisa em Virologia Animal, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Bruna Ferreira Sampaio RibeiroLaboratório de Pesquisa em Virologia Animal, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-7068-7539
Marta GiovanettiMosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte 30190-002, Brazil.ORCID 0000-0002-5849-7326
Luiz Carlos Júnior AlcântaraMosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte 30190-002, Brazil.
Sandra Coccuzzo SampaioCentro para Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, São Paulo 05503-900, Brazil.
Maria Carolina Quartim Barbosa Elias SabbagaCentro para Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0002-0501-8280
Rafael Romero NicolinoLaboratório de Bioestatística e Geoprocessamento, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-5945-9949
Zélia Inês Portela LobatoLaboratório de Pesquisa em Virologia Animal, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Maria Isabel Maldonado Coelho GuedesLaboratório de Pesquisa em Virologia Animal, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0002-6734-0216
Cesar Rossas Mota FilhoLaboratório de Microbiologia, Departamento de Engenharia Sanitária e Ambiental, Escola de Engenharia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Vincent Louis VialaCentro para Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0003-2267-9985
Bruna Coelho LopesLaboratório de Microbiologia, Departamento de Engenharia Sanitária e Ambiental, Escola de Engenharia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0002-6673-0191
Erica Azevedo CostaLaboratório de Pesquisa em Virologia Animal, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0002-5396-3818
Funding
University of Washington Arboviral Research Network (UWARN)U01AI151698 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale, PETER MACGARR RABINOWITZ · 2020 to 2026
$13.3M
CRP-ICGEB Research Grant 2020 project CRP/BRA20-03, contract CRP/20/03Minas Gerais State Research Support Foundation (FAPEMIG) APQ-02856-24NIAID NIH HHS U01 AI151698São Paulo Research Foundation (FAPESP) 2021/11944-6
6 · The paper itself
Abstract
Surveillance of swine influenza A virus (swIAV) traditionally focuses on respiratory matrices, yet emerging evidence suggests that fecal shedding and secondary environmental contamination may also contribute to viral dissemination. In this study, we collected and analyzed nasal, rectal, environmental, milk, and colostrum samples from naturally infected pigs in a commercial farm in Minas Gerais, Brazil. IAV RNA was detected in 25% of samples, including 42% from asymptomatic animals, with nasal swabs showing higher detection rates (30%) than rectal swabs (20%), though rectal Ct values were consistently higher, indicative of lower viral loads. We successfully isolated viable viruses from feces and effluent samples. Whole-genome sequencing revealed co-circulation of enzootic pH1N1 clade #2 (HA) and pN1 clade #4 (NA), alongside human-origin H3N2 sequences clustering within clade 3C.2a1b.2a.2a.1, and N2 segments related to pre-3C human lineages from 2001 to 2002. Phylogenetic and p-distance analyses support both recent reverse zoonosis and historical transmission events. Detection of complete HA/NA sequences from rectal swabs and treated effluent further emphasizes the surveillance value of non-respiratory matrices. The integration of respiratory and fecal/environmental sampling appears important to achieve more comprehensive IAV monitoring in swine herds and may have significant implications for One Health strategies in Brazil and beyond.
Indexed as
FecesInfluenza A virusInfluenza, HumanOrthomyxoviridae InfectionsSwine DiseasesVirus SheddingAnimalsBrazilGenome, ViralHumansPhylogenyRNA, ViralSwineZoonosesRNA, Viralenvironmental surveillancefecal sheddingH3N2influenza A viruspH1N1phylogeneticsreverse zoonosisswine
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Fecal and Environmental Shedding of Influenza A Virus in Brazilian Swine: Genomic Evidence of Recent Human-to-Swine Transmission. · full record | OpenQuestion