ArticleNutrients2025
Association Between Serum High Sensitivity C-Reactive Protein Levels and Low Muscle Strength Among Korean Adults.
Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Combined Association of High-Sensitivity C-Reactive Protein and Vitamin D with Short-Term Functional Outcomes in Acute Ischemic Stroke.Nutrients · 2026Article
- Article
- Review
- Joint associations of grip strength, lipid levels, and lipid-related genetic risk with atrial fibrillation.Lipids in health and disease · 2026Article
- C-reactive protein-albumin-lymphocyte (CALLY) index as a novel inflammatory marker for sarcopenia: evidence from a cross-sectional study.Turkish journal of medical sciences · 2026Article
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2 authors.
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Abstract
purposeChronic low-grade inflammation is increasingly recognized as a contributor to age-related muscle loss and functional decline, yet its association with muscle strength in Asian populations remains underexplored. Therefore, this study aimed to investigate the relationship between high-sensitivity C-reactive protein (hsCRP) and low muscle strength in Korean adults. MATERIALS AND
methodsData were obtained from 14,354 participants aged ≥ 19 years in the 7th Korea National Health and Nutrition Examination Survey (KNHANES VII, 2016-2018). Low muscle strength was defined as handgrip strength < 28 kg for men and <18 kg for women, and serum hsCRP levels were categorized as normal (<1.0 mg/L), elevated (1.0-3.0 mg/L), and high (≥3.0 mg/L). Multivariable logistic regression was used to assess the association between serum hsCRP level and low muscle strength with adjustment for possible confounders.
resultsAmong Korean adults, 27.7% had elevated or high hsCRP level, and low muscle strength was prevalent in older adults ≥ 65 years (men 22.7%, women 34.1%). Elevated hsCRP was associated with increased odds of low muscle strength in middle-aged women 40-64 years (odds ratio [OR], 1.47; 95% confidence interval [CI], 1.04-2.09) and in older women ≥ 65 years (OR, 1.34; 95% CI, 1.04-1.74). High hsCRP was associated with higher risk in older men (OR, 1.71; 95% CI, 1.06-2.75) and older women (OR, 1.66; 95% CI, 1.14-2.42).
conclusionsHigher hsCRP levels were independently associated with low muscle strength in middle-aged women and older adults. Downregulating inflammation through nutritional strategies could help prevent muscle decline with aging.
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