Evidence map›Paper›PMID 40871701›Full record

ReviewNutrients2025

Genetic Variants Influencing Individual Vitamin D Status.

Niel A Karrow, Spencer E Leuschner, Umesh K Shandilya, Bonnie A Mallard, Lauraine Wagter-Lesperance, Byram W Bridle

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Incidence and risk factors of hypocalcemia following denosumab therapy in a Saudi osteoporosis cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Niel A KarrowDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Spencer E LeuschnerDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0009-0004-6273-0815
Umesh K ShandilyaDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0003-0148-8485
Bonnie A MallardImmunoceutica Inc., Cambridge, ON N1T 1N6, Canada.ORCID 0000-0002-9853-905X
Lauraine Wagter-LesperanceImmunoceutica Inc., Cambridge, ON N1T 1N6, Canada.ORCID 0000-0002-1695-7603
Byram W BridleImmunoceutica Inc., Cambridge, ON N1T 1N6, Canada.ORCID 0000-0002-8335-1118

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D (VD) plays a critical role in human health, with deficiencies linked to a range of adverse outcomes, including compromised immune function and increased disease risk. While environmental factors such as sunlight exposure and diet influence circulating VD levels, genetic variation is a significant and underappreciated contributor to interindividual differences in serum 25-hydroxyvitamin D [25(OH)D] concentrations. This review provides a comprehensive summary of genetic variants in key genes involved in VD synthesis (e.g.,

Indexed as

Genetic VariationNutritional StatusPolymorphism, Single NucleotideVitamin DVitamin D DeficiencyCholestanetriol 26-MonooxygenaseCytochrome P450 Family 2Gene-Environment InteractionHumansOxidoreductases Acting on CH-CH Group Donors25-hydroxyvitamin D7-dehydrocholesterol reductaseCholestanetriol 26-MonooxygenaseCYP2R1 protein, humanCytochrome P450 Family 2Oxidoreductases Acting on CH-CH Group DonorsVitamin DCYP450 enzymesgenetic polymorphismsgenomic risk scorevitamin D metabolism

Identifiers

PMID40871701
PMCPMC12389392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.