Evidence map›Paper›PMID 40871697›Full record

ArticleNutrients2025

Interplays of

Brian Wang, Brandilyn A Peters-Samuelson, Kai Luo, Christina Cordero, Krista M Perreira, Amber Pirzada, Martha L Daviglus, Yang Li, Robert C Kaplan, Robert D Burk and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brian WangDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0009-0002-1144-9594
Brandilyn A Peters-SamuelsonDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kai LuoDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Christina CorderoDepartment of Psychology, University of Miami, Miami, FL 33124, USA.
Krista M PerreiraDepartment of Social Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0003-2906-0261
Amber PirzadaInstitute for Minority Health Research, University of Illinois at Chicago, Chicago, IL 60612, USA.
Martha L DaviglusDepartment of Preventive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Yang LiDepartment of Medicine and Population Health, NYU Grossman School of Medicine, New York, NY 10016, USA.
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Robert D BurkDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Funding

Genomic Architecture of Common Disease in Diverse Populations: WGS of Ongoing Hemorrhagic Stroke Study SupplementUM1HG008898 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2016 to 2020
$77.0M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HU, FRANK B, QI, QIBIN · 1998 to 2021
$8.0M
New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Epidemiology of the gut microbiome, prediabetes and diabetes in LatinosR01MD011389 · NIMHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BURK, ROBERT D, KAPLAN, ROBERT C · 2016 to 2020
$4.3M
Ultra-processed Foods, Diet Quality, and Cardiometabolic Health: An Inter-disciplinary Trans-Atlantic Collaborative ProjectR01DK120870 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Qibin Qi, Qi Sun · 2019 to 2026
$4.2M
Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolitesR01HL140976 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KAPLAN, ROBERT C, KNIGHT, ROB · 2018 to 2021
$3.3M
Cardiometabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS)R01HL136266 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KAPLAN, ROBERT C, MOSSAVAR-RAHMANI, YASMIN · 2017 to 2020
$3.1M
Human Gut Microbiome and Incident Diabetes Risk in U.S. PopulationsR01DK126698 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI QI, QIBIN, SUN, QI · 2021 to 2024
$2.5M
Metabolomics signatures underlying diet, lifestyle and gut microbiota for diabetesR01DK119268 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI QI, QIBIN · 2019 to 2022
$2.4M
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
National Heart Lung and Blood Institute R01-HL060712National Heart Lung and Blood Institute R01-HL136266National Heart Lung and Blood Institute R01-HL140976NHGRI NIH HHS UM1 HG008898NHGRI NIH HHS UM1-HG008898NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL060712NHLBI NIH HHS R01 HL136266NHLBI NIH HHS R01 HL140976NIDDK NIH HHS P30 DK111022NIDDK NIH HHS P30DK111022NIDDK NIH HHS R01 DK119268NIDDK NIH HHS R01-DK119268NIDDK NIH HHS R01 DK120870NIDDK NIH HHS R01-DK120870NIDDK NIH HHS R01 DK126698NIDDK NIH HHS R01-DK126698NIEHS NIH HHS P30 ES027792NIMHD NIH HHS R01 MD011389NIMHD NIH HHS R01-MD011389
6 · The paper itself

Abstract

BACKGROUND/

objectiveAlcohol consumption has been linked to alterations in gut microbiota and insulin resistance. The alcohol dehydrogenase 1B (ADH1B) gene plays a crucial role in alcohol catabolism, where rs1229984 variant carriers (CT/TT) catabolize ethanol at an 80-fold faster rate than non-carriers (CC). This study investigates the relationships between ADH1B gene rs1229984 mutation, alcohol consumption, gut microbiota, and insulin resistance.

methodsWe performed cross-sectional analysis on fecal metagenomic sequencing data from diabetes-free participants in a longitudinal cohort of the Hispanic Community Health Study/Study of Latinos. We used Analysis of Composition of Microbiomes to identify gut microbial species associated with alcohol consumption in non-carriers (

resultsDistinct microbial species associated with alcohol consumption were identified in non-carriers (54 species) and carriers (16 species). In non-carriers, the genotype-specific GMS modified the relationship between alcohol consumption and insulin resistance (P

conclusionsThis study suggests that the ADH1B gene rs1229984 mutation is associated with gut microbiota profiles altered by alcohol consumption. Our findings also suggest a potential role of gut microbiota in the protective association between alcohol consumption and insulin resistance in the

Indexed as

Alcohol DehydrogenaseAlcohol DrinkingGastrointestinal MicrobiomeGenotypeInsulin ResistanceAdultCross-Sectional StudiesFecesFemaleHumansLongitudinal StudiesMaleMiddle AgedADH1B protein, humanAlcohol DehydrogenaseADH1B genotypealcohol intakegut microbiomeinsulin resistanceinteraction

Identifiers

PMID40871697
PMCPMC12389023

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.