Evidence map›Paper›PMID 40871696›Full record

ReviewNutrients2025

Powering Nutrition Research: Practical Strategies for Sample Size in Multiple Regression.

Jamie A Seabrook

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jamie A SeabrookDepartment of Epidemiology and Biostatistics, Western University, London, ON N6G 2M1, Canada.ORCID 0000-0003-4297-6450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Robust statistical analysis is essential for advancing evidence-based nutrition research, particularly when investigating the complex relationships between dietary exposure and health outcomes. Multiple regression is a widely used analytical technique in nutrition studies due to its ability to control for confounding variables and assess multiple predictors simultaneously. However, the reliability, validity, and generalizability of findings from regression analyses depend heavily on having an appropriate sample size. Despite its importance, many published nutrition studies do not include formal sample size justifications or power calculations, leading to a high risk of Type II errors and reduced interpretability of results. This methodological review examines three commonly used approaches to sample size determination in multiple regression analysis: the rule of thumb, variance explained (R

Indexed as

Nutritional SciencesResearch DesignHumansRegression AnalysisReproducibility of ResultsSample Sizebeta weightseffect sizemultiple regressionmultivariable modelingnutrition researchpower analysisresearch designsample size calculationstatistical powervariance explained

Identifiers

PMID40871696
PMCPMC12389515

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.