Evidence map›Paper›PMID 40871615›Full record

ArticleNutrients2025

Balancing the Cellular Inflammatory-Homeostatic Axis Through Natural Ingredient Supplementation.

Valentina Bordano, Chiara Gerbino, Valentina Boscaro, Patrizia Rubiolo, Arianna Marengo, Stefania Pizzimenti, Marie Angèle Cucci, Stefania Cannito, Jessica Nurcis, Margherita Gallicchio and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Valentina BordanoDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.ORCID 0009-0001-1219-2949
Chiara GerbinoDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Valentina BoscaroDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.ORCID 0000-0002-3344-8624
Patrizia RubioloDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.ORCID 0000-0002-6819-2614
Arianna MarengoDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.ORCID 0000-0002-1777-2264
Stefania PizzimentiDepartment of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.ORCID 0000-0001-6937-8632
Marie Angèle CucciDepartment of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
Stefania CannitoDepartment of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.ORCID 0000-0001-9883-6882
Jessica NurcisDepartment of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
Margherita GallicchioDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Simona Federica SpampinatoDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.ORCID 0000-0001-7564-1986
Luigi CangemiDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Claudia BoccaDepartment of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
Chiara DianzaniDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.ORCID 0000-0002-2246-3183
Arianna Carolina RosaDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.ORCID 0000-0002-6139-9241
Elisa BenettiDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.ORCID 0000-0002-4481-0756

Funding

Acfp srl BENE_CT_RIC_23_01.
6 · The paper itself

Abstract

BACKGROUND/

objectivesDietary supplements are sources of nutrients or other substances that added to a healthy lifestyle help to preserve human homeostasis. Since inflammation is one of the major contributors to the alteration of homeostasis, this work investigated the effects of a multi-ingredient dietary supplement on human macrophages, cells involved in the inflammatory response.

methodsTHP-1 cells were differentiated into macrophage-like cells and polarized in M

resultsOur results showed that the dietary supplement promoted M

conclusionsOur results demonstrate how a combination of natural active ingredients may contribute to the maintenance of homeostasis in human cells.

Indexed as

Dietary SupplementsHomeostasisInflammationMacrophagesAnimalsAntioxidantsCell MovementCytokinesFibroblastsHumansHuman Umbilical Vein Endothelial CellsMiceNF-kappa BOxidative StressTHP-1 CellsAntioxidantsCytokinesNF-kappa Bdietary supplementshomeostasisinflammationmacrophagesoxidative stress

Identifiers

PMID40871615
PMCPMC12389121

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.