Reversed-Phase (RP) and Hydrophilic Interaction (HILIC) Separation Mechanisms for the Assay of Nicotine and E-Cigarette Liquids.

Răzvan Moisi, Mircea-Alexandru Comănescu, Andrei-Valentin Medvedovici

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Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors.

Răzvan MoisiDepartment of Analytical & Physical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Ave. #90-92, 050663 Bucharest, Romania.

Mircea-Alexandru ComănescuDepartment of Analytical & Physical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Ave. #90-92, 050663 Bucharest, Romania.ORCID 0000-0002-3075-436X

Andrei-Valentin MedvedoviciDepartment of Analytical & Physical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Ave. #90-92, 050663 Bucharest, Romania.ORCID 0000-0003-2647-2906

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotine is a highly used addictive substance that has recently also become available through electronic cigarettes. Here we present a study of nicotine from e-cigarette liquids through reversed-phase (RP) and hydrophilic interaction (HILIC) liquid chromatography. Multiple aqueous mobile-phase additives are considered for the RP mechanism, focusing on chaotropic agents, mobile-phase concentrations and mixing ratios, and column temperature. Sample preparation was conducted by toluene liquid-liquid extraction of e-cigarette liquids diluted with aqueous 25 mM NaHCO

Indexed as

Chromatography, Reverse-PhaseElectronic Nicotine Delivery SystemsNicotineChromatography, LiquidHydrophobic and Hydrophilic InteractionsLiquid-Liquid ExtractionNicotinechaotropic agentsHILICion pairingreversed phase

Identifiers

PMID40871595

DOI10.3390/molecules30163443

PMCPMC12388816

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.