Evidence map›Paper›PMID 40871533›Full record

ArticleMolecules (Basel, Switzerland)2025

Optimization of Extraction Methods for NMR and LC-MS Metabolite Fingerprint Profiling of Botanical Ingredients in Food and Natural Health Products (NHPs).

Varathan Vinayagam, Arunachalam Thirugnanasambandam, Subramanyam Ragupathy, Ragupathy Sneha, Steven G Newmaster

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Varathan VinayagamCollege of Biological Science, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0009-0005-9226-447X
Arunachalam ThirugnanasambandamCollege of Biological Science, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0001-7948-2257
Subramanyam RagupathyCollege of Biological Science, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0002-5181-005X
Ragupathy SnehaCollege of Biological Science, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0009-0001-1882-6287
Steven G NewmasterCollege of Biological Science, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0002-8707-7769

Funding

Natural Health Product Research Alliance, University of Guelph 053312
6 · The paper itself

Abstract

Metabolite fingerprint profiling is a robust tool for verifying suppliers of authentic botanical ingredients. While comparative studies exist, few apply identical conditions across multiple species; this study utilized a cross-species comparison to identify versatile solvents despite biochemical variability. Multiple solvents were used for sample extraction prior to analysis by proton NMR and liquid chromatography-mass spectrometry (LC-MS) for multiple botanicals including

Indexed as

Biological ProductsMetabolomicsPlant ExtractsChromatography, LiquidLiquid Chromatography-Mass SpectrometryMagnetic Resonance SpectroscopyMass SpectrometrySolventsBiological ProductsPlant ExtractsSolventsbotanical authenticationchemotaxonomyliquid chromatography–mass spectrometrymetabolite fingerprintingnuclear magnetic resonancesolvent extraction

Identifiers

PMID40871533
PMCPMC12388471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.