Evidence map›Paper›PMID 40871494›Full record

ArticleMolecules (Basel, Switzerland)2025

Discovery of (

Liuzeng Chen, Xiaoyu Zheng, Jiahui Li, Bin Zhou, Min Tao, Yuetian Yang, Yi Wang, Hao Zhan, Guoping Zhang, Jingbo Shi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liuzeng ChenSchool of Biology, Food and Environment, Hefei University, Hefei 230601, China.ORCID 0000-0001-6610-1734
Xiaoyu ZhengSchool of Biology, Food and Environment, Hefei University, Hefei 230601, China.ORCID 0009-0006-6698-127X
Jiahui LiSchool of Biology, Food and Environment, Hefei University, Hefei 230601, China.ORCID 0009-0006-6858-8607
Bin ZhouSchool of Biology, Food and Environment, Hefei University, Hefei 230601, China.ORCID 0009-0006-2931-8380
Min TaoSchool of Biology, Food and Environment, Hefei University, Hefei 230601, China.ORCID 0009-0003-3120-9851
Yuetian YangSchool of Biology, Food and Environment, Hefei University, Hefei 230601, China.ORCID 0009-0006-2068-9548
Yi WangSchool of Biology, Food and Environment, Hefei University, Hefei 230601, China.ORCID 0009-0007-4109-0582
Hao ZhanSchool of Biology, Food and Environment, Hefei University, Hefei 230601, China.ORCID 0009-0005-2877-2226
Guoping ZhangCollege of Chemistry and Materials Science, Huaibei Normal University, Huaibei 235000, China.ORCID 0000-0003-3913-2257
Jingbo ShiSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei 230601, China.ORCID 0000-0002-9204-0709
Xingxing ZhangSchool of Biology, Food and Environment, Hefei University, Hefei 230601, China.ORCID 0009-0006-9762-1648
Banfeng RuanSchool of Biology, Food and Environment, Hefei University, Hefei 230601, China.ORCID 0000-0001-7913-7824

Funding

The Anhui Province Excellent Research and Innovation Team Project for Universities 2023AH010050The National Natural Science Foundation of China 22207028The Provincial Key Project of Education Department in Anhui 2022AH050394
6 · The paper itself

Abstract

The pyrin domain-containing protein 3 (NLRP3) inflammasome may be a potential target for the treatment of inflammatory bowel disease (IBD), and inhibiting the activation of the NLRP3 inflammasome is of great significance for the treatment of IBD. In this study, 27 novel chalcone derivatives were designed and synthesized. Enzyme-linked immunosorbent assay (ELISA) analysis revealed that most of the compounds inhibited IL-1β secretion, with

Indexed as

Anti-Inflammatory AgentsColitisInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAdministration, OralAnimalsDextran SulfateDisease Models, AnimalDrug DiscoveryHumansInterleukin-1betaMacrophagesMaleMiceMice, Inbred C57BLMolecular Docking SimulationAnti-Inflammatory AgentsDextran SulfateInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReactive Oxygen Specieschalcone derivativesIBDinflammationinhibitor

Identifiers

PMID40871494
PMCPMC12388496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.