Evidence map›Paper›PMID 40871492›Full record

ArticleMolecules (Basel, Switzerland)2025

Evaluation of the Cytotoxic Activity of Nanostructured Lipid Carrier Systems for Fatty Acid Amides and Silk Fibroins in Breast Cancer Cell Lines.

Sandro da Silva Borges, Sued Eustáquio Mendes Miranda, Victor Hugo de Souza Marinho, André Luís Branco de Barros, Sergio Yoshioka, Lorane Izabel da Silva Hage-Melim, Ana Carolina de Jesus Silva, Irlon Maciel Ferreira, Anna Eliza Maciel de Faria Mota Oliveira

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sandro da Silva BorgesBiocatalysis and Applied Organic Synthesis Laboratory, Federal University of Amapá, University Campus Marco Zero do Equador, Rodovia Josmar Chaves Pinto, Km 02, Macapá 68902-280, AP, Brazil.ORCID 0000-0002-8899-8789
Sued Eustáquio Mendes MirandaDepartment of Clinical and Toxicological Analyses, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Belo Horizonte 31270-901, MG, Brazil.
Victor Hugo de Souza MarinhoBiocatalysis and Applied Organic Synthesis Laboratory, Federal University of Amapá, University Campus Marco Zero do Equador, Rodovia Josmar Chaves Pinto, Km 02, Macapá 68902-280, AP, Brazil.
André Luís Branco de BarrosDepartment of Clinical and Toxicological Analyses, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-7641-6585
Sergio YoshiokaBiochemistry and Biomaterials Laboratory, Institute of Chemistry of São Carlos, University of São Paulo, Av. Trabalhador São-Carlense 400, São Carlos 13560-970, SP, Brazil.ORCID 0000-0003-0016-733X
Lorane Izabel da Silva Hage-MelimLaboratory of Pharmaceutical and Medicinal Chemistry, Federal University of Amapá, University Campus Marco Zero do Equador, Rodovia Josmar Chaves Pinto, Km 02, Macapá 68902-280, AP, Brazil.
Ana Carolina de Jesus SilvaLaboratory of Pharmaceutical and Medicinal Chemistry, Federal University of Amapá, University Campus Marco Zero do Equador, Rodovia Josmar Chaves Pinto, Km 02, Macapá 68902-280, AP, Brazil.
Irlon Maciel FerreiraBiocatalysis and Applied Organic Synthesis Laboratory, Federal University of Amapá, University Campus Marco Zero do Equador, Rodovia Josmar Chaves Pinto, Km 02, Macapá 68902-280, AP, Brazil.ORCID 0000-0002-4517-0105
Anna Eliza Maciel de Faria Mota OliveiraLaboratory of Phytopharmaceutical Nanobiotechnology, Federal University of Amapá, University Campus Marco Zero do Equador, Rodovia Josmar Chaves Pinto, Km 02, Macapá 68902-280, AP, Brazil.ORCID 0000-0001-9337-4519

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer, a highly prevalent malignancy among women, continues to pose a significant global health challenge, as conventional therapies are often limited by adverse effects. This study developed and evaluated nanostructured lipid carriers (NLCs) encapsulating fatty acid amides (FAAs) semi-synthesized from andiroba oil and combined with silk fibroin (SF) as a novel therapeutic strategy. Methods: FAAs were synthesized via direct amidation and characterized by GC-MS, FT-IR, and

Indexed as

AmidesAntineoplastic AgentsBreast NeoplasmsDrug CarriersFatty AcidsFibroinsLipidsNanostructuresAnimalsCell Line, TumorCell SurvivalFemaleHumansMiceMolecular Docking SimulationParticle SizeAmidesAntineoplastic AgentsDrug CarriersFatty AcidsFibroinsLipidsandirobaBiomaterialsBombyx moribreast cancercannabinoid receptorcytotoxicity

Identifiers

PMID40871492
PMCPMC12388404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.