Evidence map›Paper›PMID 40871454›Full record

ArticleMicroorganisms2025

BCL-2 Multi-Strain Probiotics for Immunomodulation In Vitro and In Vivo Alleviation of Atopic Dermatitis.

MinKyung Sung, Seongrok Sim, Ahyoung Lim, Jin Seok Moon, JongIk Jeon, Keon Heo, Woongkwon Kwak, Myeong Soo Park, Jungki Kwak, EunYoung Park and 1 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Monoclonal Antibodies in Pediatric Atopic Dermatitis; Efficacy and Safety.Current therapeutic research, clinical and experimental · 2026
    Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

MinKyung SungLotte R&D Center, Seoul 07594, Republic of Korea.
Seongrok SimResearch Center, BIFIDO Co., Ltd., Hongcheon 25117, Republic of Korea.ORCID 0009-0003-4466-7958
Ahyoung LimLotte R&D Center, Seoul 07594, Republic of Korea.
Jin Seok MoonResearch Center, BIFIDO Co., Ltd., Hongcheon 25117, Republic of Korea.
JongIk JeonResearch Center, BIFIDO Co., Ltd., Hongcheon 25117, Republic of Korea.ORCID 0000-0002-7917-0648
Keon HeoResearch Center, BIFIDO Co., Ltd., Hongcheon 25117, Republic of Korea.ORCID 0000-0001-5874-9389
Woongkwon KwakLotte R&D Center, Seoul 07594, Republic of Korea.
Myeong Soo ParkResearch Center, BIFIDO Co., Ltd., Hongcheon 25117, Republic of Korea.
Jungki KwakLotte R&D Center, Seoul 07594, Republic of Korea.
EunYoung ParkDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Seokmin YoonLotte R&D Center, Seoul 07594, Republic of Korea.ORCID 0000-0002-7004-5947

Funding

the Korea Ministry of Trade, Industry, and Energy (MOTIE) 20014744
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic inflammatory disorder with immune imbalance, including elevated IgE levels and mast cell activation mediated by Th2 cytokines, leading to allergic inflammation and impaired skin barrier function. Current treatment limitations highlight the need for safer and more effective AD alternatives. We aimed to evaluate the therapeutic effects of multi-strain probiotics, BCL-2 (comprising

Indexed as

atopic dermatitisBifidobacterium longumhistopathologyhypersensitivityimmune modulationinflammatory cytokinesLactiplantibacillus plantarummicepro-inflammatory mediators

Identifiers

PMID40871454
PMCPMC12388198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.