Evidence map›Paper›PMID 40871383›Full record

ArticleMicroorganisms2025

Altered Gut Microbiota and Predicted Immune Dysregulation in Early Childhood SARS-CoV-2 Infection.

Dong Hyun Kim, Byung Ok Kwak, Ky Young Cho

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dong Hyun KimDepartment of Pediatrics, Inha University College of Medicine, 27, Inhang-ro, Jung-gu, Incheon 22332, Republic of Korea.ORCID 0000-0001-9883-0229
Byung Ok KwakDepartment of Pediatrics, Inha University College of Medicine, 27, Inhang-ro, Jung-gu, Incheon 22332, Republic of Korea.
Ky Young ChoDepartment of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, 1 Singil-ro, Yeongdeungpo-gu, Seoul 07441, Republic of Korea.ORCID 0000-0002-0565-8077

Funding

Hallym University Medical Center Research FundHallym University Research Grant, 2020 HURF-2020-22SNUH Lee Kun-hee Child Cancer & Rare Disease Project, Republic of Korea 25C-069-0100
6 · The paper itself

Abstract

The gut microbiome plays a key role in immune regulation. Young children experience rapid microbiome development, yet data on its alteration during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain limited. This study aimed to characterize gut microbiome changes and immune-related pathway alterations in young children with coronavirus disease 2019 (COVID-19). Eighteen children under 2 years old with confirmed SARS-CoV-2 infection and seven healthy controls were enrolled between December 2021 and June 2022. Stool samples were analyzed using 16S rRNA gene sequencing. In children with COVID-19, the gut microbiome exhibited an increase in Bacteroidota and Bacillota, whereas Actinomycetota and Pseudomonadota were reduced, with higher abundances of

Indexed as

coronavirus disease 2019 (COVID-19)dysbiosisearly childhoodmicrobiotasevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Identifiers

PMID40871383
PMCPMC12388501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.