Evidence map›Paper›PMID 40871335›Full record

ArticleMicroorganisms2025

Development of a Bacterial Lysate from Antibiotic-Resistant Pathogens Causing Hospital Infections.

Sandugash Anuarbekova, Azamat Sadykov, Dilnaz Amangeldinova, Marzhan Kanafina, Darya Sharova, Gulzhan Alzhanova, Rimma Nurgaliyeva, Ardak Jumagaziyeva, Indira Tynybayeva, Aikumys Zhumakaeva and 3 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sandugash AnuarbekovaScientific and Analytical Center "Biomedpreparat" LLP, Stepnogorsk 021500, Kazakhstan.
Azamat SadykovScientific and Analytical Center "Biomedpreparat" LLP, Stepnogorsk 021500, Kazakhstan.
Dilnaz AmangeldinovaScientific and Analytical Center "Biomedpreparat" LLP, Stepnogorsk 021500, Kazakhstan.
Marzhan KanafinaScientific and Analytical Center "Biomedpreparat" LLP, Stepnogorsk 021500, Kazakhstan.ORCID 0009-0004-0559-153X
Darya SharovaScientific and Analytical Center "Biomedpreparat" LLP, Stepnogorsk 021500, Kazakhstan.ORCID 0009-0001-8698-0585
Gulzhan AlzhanovaScientific and Analytical Center "Biomedpreparat" LLP, Stepnogorsk 021500, Kazakhstan.
Rimma NurgaliyevaScientific and Analytical Center "Biomedpreparat" LLP, Stepnogorsk 021500, Kazakhstan.ORCID 0009-0007-4378-4318
Ardak JumagaziyevaScientific Center for Anti-Infectious Drugs, Almaty 050000, Kazakhstan.
Indira TynybayevaScientific and Analytical Center "Biomedpreparat" LLP, Stepnogorsk 021500, Kazakhstan.ORCID 0000-0001-6984-3856
Aikumys ZhumakaevaScientific and Analytical Center "Biomedpreparat" LLP, Stepnogorsk 021500, Kazakhstan.
Aralbek RsaliyevNational Holding "QazBioPharm", Astana 010000, Kazakhstan.
Yergali AbduraimovNational Holding "QazBioPharm", Astana 010000, Kazakhstan.
Yerkanat N KanafinFaculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan.ORCID 0000-0002-1052-8533

Funding

Ministry of Science and Higher Education of the Republic of Kazakhstan IRN BR218004/0223
6 · The paper itself

Abstract

Biotechnological research increasingly focuses on developing new drugs to counter the rise of antibiotic-resistant strains in hospitals. This study aimed to create bacterial lysates from antibiotic-resistant pathogens isolated from patients and medical instruments across hospital departments. Identification was performed based on morphological, cultural, and biochemical characteristics, as well as 16S rRNA gene sequencing using the BLAST algorithm. Strain viability was assessed using the Miles and Misra method, while sensitivity to eight antibacterial drug groups and biosafety between cultures were evaluated using agar diffusion. From 15 clinical sources, 25 pure isolates were obtained, and their phenotypic and genotypic properties were studied. Carbohydrate fermentation testing confirmed that the isolates belonged to the genera

Indexed as

antibiotic resistancebacterial lysateclinical isolatesFrench press homogenizationrespiratory pathogens

Identifiers

PMID40871335
PMCPMC12388342

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.