Evidence map›Paper›PMID 40871329›Full record

ArticleMicroorganisms2025

Effects of cRG-I Prebiotic Treatment on Gut Microbiota Composition and Metabolic Activity in Dogs In Vitro.

Sue McKay, Helen Churchill, Matthew R Hayward, Brian A Klein, Lieven Van Meulebroek, Jonas Ghyselinck, Massimo Marzorati

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Microorganisms · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sue McKayNutriLeads BV, Bronland 12N, 6708 WH Wageningen, The Netherlands.
Helen Churchilldsm-firmenich, 60 Westview Street, Lexington, MA 02421, USA.
Matthew R Haywarddsm-firmenich, 60 Westview Street, Lexington, MA 02421, USA.
Brian A Kleindsm-firmenich, 60 Westview Street, Lexington, MA 02421, USA.ORCID 0000-0002-7233-2114
Lieven Van MeulebroekProDigest BV, Technologiepark 82, 9052 Zwijnaarde, Belgium.
Jonas GhyselinckProDigest BV, Technologiepark 82, 9052 Zwijnaarde, Belgium.
Massimo MarzoratiProDigest BV, Technologiepark 82, 9052 Zwijnaarde, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-dose carrot rhamnogalacturonan-I (cRG-I) has shown consistent modulatory effects on the gut microbiota and immune function in humans. In this study we investigated its effects on the microbial composition and metabolite production of the gut microbiota of small (5-10 kg), medium-sized (10-27 kg), and large (27-45 kg) dogs, using inulin and xanthan as comparators. Fecal samples from six dogs of each size group were evaluated. Overall microbiome composition, assessed using metagenomic sequencing, was shown to be driven mostly by dog size and not treatment. There was a clear segregation in the metabolic profile of the gut microbiota of small dogs versus medium-sized and large dogs. The fermentation of cRG-I specifically increased the levels of acetate/propionate-producing

Indexed as

canine gut microbiomecarrot rhamnogalacturonan-IcRG-Idietary fibermetagenomicsprebiotic

Identifiers

PMID40871329
PMCPMC12388317

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.