Evidence map›Paper›PMID 40871287›Full record

ArticleMicroorganisms2025

Group A Streptococcal Invasive Infections Among Children in Cyprus.

Maria Koliou, Gavriella Ioannou Vassiliadou, Athina Aristidou, Petros Ladas, Andreas Sergis, Maria Argyrou, Myria Charalambous, Markella Marcou, Maria Alexandrou, Juliana Coelho and 3 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria KoliouMedical School, University of Cyprus, Nicosia 2115, Cyprus.ORCID 0000-0003-0647-9967
Gavriella Ioannou VassiliadouMedical School, University of Cyprus, Nicosia 2115, Cyprus.
Athina AristidouArchbishop Makarios Hospital, Nicosia 2012, Cyprus.
Petros LadasMedical School, University of Cyprus, Nicosia 2115, Cyprus.
Andreas SergisArchbishop Makarios Hospital, Nicosia 2012, Cyprus.
Maria ArgyrouArchbishop Makarios Hospital, Nicosia 2012, Cyprus.
Myria CharalambousArchbishop Makarios Hospital, Nicosia 2012, Cyprus.
Markella MarcouArchbishop Makarios Hospital, Nicosia 2012, Cyprus.
Maria AlexandrouLarnaca General Hospital, Larnaca 6043, Cyprus.
Juliana CoelhoUK Health Security Agency, London NW9 5EQ, UK.
Yan RyanUK Health Security Agency, London NW9 5EQ, UK.
Androulla EfstratiouUK Health Security Agency, London NW9 5EQ, UK.ORCID 0000-0002-7376-7160
Stella MazeriRoslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, UK.ORCID 0000-0002-4591-8267

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increase in invasive group A streptococcal (iGAS) infections among children under 15 years of age was reported in several countries between late 2022 and early 2023. This retrospective study aims to describe the epidemiology and clinical features of iGAS infections in children in Cyprus during the same period. Medical records of patients under 16 years old admitted with iGAS infection to the Archbishop Makarios Hospital, the only tertiary paediatric referral centre in Cyprus, between 1 January 2021 and 30 June 2024, were reviewed. Twenty-two cases were identified, of which twenty were classified as confirmed and two as probable. Half of the cases occurred in children aged 0-4 years, and 59% were recorded between December 2022 and April 2023. Scarlet fever was diagnosed in six children, five of whom developed pneumonia and empyema. Streptococcal toxic shock syndrome (STSS) was observed in five patients, resulting in two deaths and one case requiring prolonged extracorporeal membrane oxygenation (ECMO). The overall case fatality rate was 9.1%.

Indexed as

childreninvasive group A streptococcal infectionsscarlet feverstreptococcal toxic shock syndrome

Identifiers

PMID40871287
PMCPMC12388716

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.