Evidence map›Paper›PMID 40871151›Full record

ArticlePolymers2025

Development and Characterization of Polymer Blends Based on Polyvinyl Alcohol for Application as Pharmaceutical Dosage Form.

Zarina A Kenessova, Grigoriy A Mun, Perizat I Urkimbayeva, Assel K Toktabayeva, Raikhan K Rakhmetullayeva, Bayana B Yermukhambetova, Zhazira Kenzhebai, Zhuldyzay T Kurmanova, Mubarak Yermaganbetov, Adilet Zh Alikulov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zarina A KenessovaDepartment of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0003-2768-824X
Grigoriy A MunDepartment of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0002-4984-7937
Perizat I UrkimbayevaDepartment of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0001-7775-0238
Assel K ToktabayevaDepartment of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0002-1313-8696
Raikhan K RakhmetullayevaDepartment of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0003-1002-2046
Bayana B YermukhambetovaDepartment of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0003-4950-0367
Zhazira KenzhebaiDepartment of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.
Zhuldyzay T KurmanovaDepartment of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0003-1611-4558
Mubarak YermaganbetovDepartment of Chemical and Biochemical Engineering, Satbayev University, Almaty 050013, Kazakhstan.ORCID 0009-0005-7670-6899
Adilet Zh AlikulovDepartment of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0003-0380-0612

Funding

The Committee of Science of the Ministry of Science and Higher Education of the Republic of Ka-zakhstan No. AP19679683, No. BR24992950 and No. BR21882289
6 · The paper itself

Abstract

Mixtures containing polyvinyl alcohol (PVA) and methylcellulose (MC) were obtained and used to synthesize hydrogels in various ratios of components. The swelling kinetics of the resulting hydrogels were studied, revealing that the equilibrium swelling degree in artificial saliva is nearly twice as high as in water. It was found that increasing the volumetric content of PVA in the mixture leads to a higher swelling degree. The kinetics of active pharmaceutical ingredient (API) sorption and release from the hydrogels were also investigated. It was demonstrated that hydrogels with a higher PVA content exhibit greater sorption capacity; however, the release of the API from such samples occurs at a slower rate. For the first time, the mucoadhesive properties of PVA-MC-based hydrogels were studied. It was established that the PVA-MC hydrogel with a ratio of 6:4 vol.% remained on the surface of the porcine cheek mucosa for two days, the 5.5:4.5 vol.% sample detached after 24 h, and the 5:5 vol.% sample adhered for approximately 10 h. These findings confirm the mucoadhesive potential of the hydrogels and their suitability for buccal drug delivery forms. The synthesized PVA-MC hydrogels are promising for applications in medicine and pharmacology.

Indexed as

active pharmaceutical ingredienthydrogelsmethylcellulosemucoadhesive propertiespolyvinyl alcohol

Identifiers

PMID40871151
PMCPMC12389391

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.