Evidence map›Paper›PMID 40871073›Full record

ArticlePharmaceutics2025

Drug Metabolism and Pharmacokinetic Evaluation of a Novel RNase H2 Inhibitor for the Treatment of Triple-Negative Breast Cancer.

Yang Wang, Huan Xie, Jing Ma, Ting Du, Song Gao, Yuan Chen, Shiaw-Yih Lin, Dong Liang

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Therapeutic assessment ofFrontiers in oncology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang WangDepartment of Pharmaceutical Science, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004-9987, USA.
Huan XieDepartment of Pharmaceutical Science, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004-9987, USA.ORCID 0000-0002-0591-5619
Jing MaDepartment of Pharmaceutical Science, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004-9987, USA.ORCID 0000-0002-9233-0247
Ting DuDepartment of Pharmaceutical Science, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004-9987, USA.ORCID 0000-0002-7705-6913
Song GaoDepartment of Pharmaceutical Science, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004-9987, USA.ORCID 0000-0003-2361-3494
Yuan ChenDepartment of Pharmaceutical Science, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004-9987, USA.ORCID 0000-0001-8676-0913
Shiaw-Yih LinDepartment of Systems Biology, MD Anderson Cancer Center, Houston, TX 77030-1515, USA.
Dong LiangDepartment of Pharmaceutical Science, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004-9987, USA.ORCID 0000-0001-6632-8066

Funding

Targeted Nano-drug-delivery-systems of Frist-in-class Drugs for CRPC: PK/PD Evaluation and Combination TherapyU54MD007605 · NIMHD · TEXAS SOUTHERN UNIVERSITY · PI Song Gao · 2020 to 2026
$22.0M
RNase H2 is a novel therapeutic target in triple negative breast cancerR01CA251206 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIN, SHIAW-YIH · 2021 to 2025
$1.9M
Cancer Prevention & Research Institute of Texas RP240430NCI NIH HHS R01 CA251206NCI NIH HHS R01CA251206NIH/NIMHD U54MD007605NIMHD NIH HHS U54 MD007605
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

drug metabolismpharmacokinetic evaluationRNase H2 inhibitor R14

Identifiers

PMID40871073
PMCPMC12389022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.