Evidence map›Paper›PMID 40871070›Full record

ArticlePharmaceutics2025

CUSP06, a Novel CDH6-Targeted Antibody-Drug Conjugate, Demonstrates Antitumor Efficacy in Multiple CDH6-Expressing Human Cancer Models.

Wei Lu, Jing Shi, Wentao Zhang, Nicole Covino, Amy Penticoff, Robert Phillips, John Cogswell, Laurie Tatalick, Stephanie Pasas-Farmer, Jianjian Zhang and 6 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wei LuOnCusp Therapeutics, 433 Broadway, New York, NY 10013, USA.
Jing ShiMultitude Therapeutics, Building No. 10, 159 Tianzhou Road, Xuhui District, Shanghai 200235, China.
Wentao ZhangOnCusp Therapeutics, 433 Broadway, New York, NY 10013, USA.
Nicole CovinoOnCusp Therapeutics, 433 Broadway, New York, NY 10013, USA.
Amy PenticoffOnCusp Therapeutics, 433 Broadway, New York, NY 10013, USA.
Robert PhillipsOnCusp Therapeutics, 433 Broadway, New York, NY 10013, USA.
John CogswellOnCusp Therapeutics, 433 Broadway, New York, NY 10013, USA.
Laurie TatalickOnCusp Therapeutics, 433 Broadway, New York, NY 10013, USA.
Stephanie Pasas-FarmerOnCusp Therapeutics, 433 Broadway, New York, NY 10013, USA.
Jianjian ZhangMultitude Therapeutics, Building No. 10, 159 Tianzhou Road, Xuhui District, Shanghai 200235, China.
Caiwei ChenMultitude Therapeutics, Building No. 10, 159 Tianzhou Road, Xuhui District, Shanghai 200235, China.
Yixuan WangMultitude Therapeutics, Building No. 10, 159 Tianzhou Road, Xuhui District, Shanghai 200235, China.
Huiyan ShiMultitude Therapeutics, Building No. 10, 159 Tianzhou Road, Xuhui District, Shanghai 200235, China.
Shuhui LiuMultitude Therapeutics, 3698A Haven Ave, Redwood City, CA 94063, USA.
Xun MengMultitude Therapeutics, Building No. 10, 159 Tianzhou Road, Xuhui District, Shanghai 200235, China.
Eric SlosbergOnCusp Therapeutics, 433 Broadway, New York, NY 10013, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ADC (antibody-drug conjugate)cadherin-6CDH6cholangiocarcinomaexatecanK-cadherinovarian canceruterine cancer

Identifiers

PMID40871070
PMCPMC12388900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.