Evidence map›Paper›PMID 40871066›Full record

ReviewPharmaceutics2025

Harnessing Phytonanotechnology to Tackle Neglected Parasitic Diseases: Focus on Chagas Disease and Malaria.

Manuela García, María S Magi, Mónica C García

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antibacterial properties ofFrontiers in nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Manuela GarcíaDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Science Building 2, Haya de la Torre and Medina Allende, Ciudad Universitaria, Córdoba X5000HUA, Argentina.ORCID 0000-0002-6809-4723
María S MagiDepartamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Science Building 2, Haya de la Torre and Medina Allende, Ciudad Universitaria, Córdoba X5000HUA, Argentina.ORCID 0009-0007-8482-4144
Mónica C GarcíaDepartamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Science Building 2, Haya de la Torre and Medina Allende, Ciudad Universitaria, Córdoba X5000HUA, Argentina.ORCID 0000-0002-1943-4891

Funding

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación FONCyT-program PICT 2021-0159Consejo Nacional de Investigaciones Científicas y Técnicas PIBAA 2022-2023 No: 28720210101293CO, RESOL-2022-1930-APNDIR#CONICETUniversidad Nacional de Córdoba SecyT-Formar No: 33820230100458CB, Res. 258/2023
6 · The paper itself

Abstract

Neglected parasitic diseases such as Chagas disease and malaria continue to pose major public health challenges, particularly in low-resource settings. Current therapies are often limited by high toxicity, poor efficacy, drug resistance, and limited accessibility. Phytochemicals, naturally occurring compounds in plants, have played a crucial role in medicine since ancient times and have gained renewed attention for their demonstrated antiparasitic activity. However, many products of natural origin (PNOs) face significant barriers to clinical use, including poor solubility, low bioavailability, and chemical instability. These limitations have driven researchers to explore alternative and innovative approaches based on the use of PNOs to tackle these parasitic infections more effectively. This review provides a comprehensive overview of key PNOs with proven activity against

Indexed as

Chagas diseasedelivery of products of natural originmalarianatural productsphytonanomedicineplant-based bioactive compounds

Identifiers

PMID40871066
PMCPMC12389517

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.