ReviewFoods (Basel, Switzerland)2025
The Role of Olive Oil Polyphenols in Osteosarcopenic Obesity-Related Biological Domains: A Systematic Review of Current Evidence.
Review in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Antioxidant and Anti-Osteoclastogenic Potential of Olive Oil Dregs Extracts.Molecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteosarcopenic obesity (OSO) is an emerging syndrome characterized by the coexistence of obesity, sarcopenia, and osteoporosis, primarily affecting aging populations. Nutrition, especially polyphenol-rich foods like extra virgin olive oil (EVOO), may play a preventive or therapeutic role in OSO. This review aims to critically examine evidence from in vitro, in vivo, and human studies on the effects of olive oil polyphenols on OSO-related biological domains.
methodsThis systematic review followed PRISMA guidelines. Studies were identified from PubMed and Google Scholar using MeSH terms related to olive oil, polyphenols, and OSO-associated conditions. In vitro and in vivo studies (both in animal and human models) published in the last ten years were included. The study protocol was registered with PROSPERO (CRD420251077836).
resultsFifteen studies were included: eight in vitro, four in vivo on animal models, and three human trials. Phenolic compounds such as hydroxytyrosol, oleuropein, oleocanthal, and oleacein demonstrated antioxidant, anti-inflammatory, anti-adipogenic, and osteo-/myo-protective effects. These compounds modulated key metabolic pathways and gene expression related to adipogenesis, bone metabolism, and muscle integrity.
conclusionsOlive oil polyphenols exhibit promising biological effects on the tissues involved in OSO. Although evidence is mostly preclinical, selected compounds (notably hydroxytyrosol and oleuropein) may serve as adjuncts in nutritional strategies for OSO prevention.
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Registered trials
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