Evidence map›Paper›PMID 40870386›Full record

SynthesisMedicina (Kaunas, Lithuania)2025

Efficacy and Safety of Radioligand Therapy with Actinium-225 DOTATATE in Patients with Advanced, Metastatic or Inoperable Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis.

Alessio Rizzo, Alessio Imperiale, Salvatore Annunziata, Roberto C Delgado Bolton, Domenico Albano, Francesco Fiz, Arnoldo Piccardo, Marco Cuzzocrea, Gaetano Paone, Giorgio Treglia

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessio RizzoDepartment of Nuclear Medicine, Candiolo Cancer Institute, FPO-IRCCS, 10060 Turin, Italy.ORCID 0009-0007-5438-8230
Alessio ImperialeNuclear Medicine, University Hospitals of Strasbourg, University of Strasbourg, 67200 Strasbourg, France.
Salvatore AnnunziataNuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Roberto C Delgado BoltonDepartment of Diagnostic Imaging (Radiology) and Nuclear Medicine, University Hospital San Pedro and Centre for Biomedical Research of La Rioja (CIBIR), 26006 Logroño, Spain.ORCID 0000-0002-8071-6513
Domenico AlbanoDepartment of Nuclear Medicine, ASST Spedali Civili di Brescia and University of Brescia, 25123 Brescia, Italy.ORCID 0000-0003-0810-6494
Francesco FizDepartment of Nuclear Medicine, Ente Ospedaliero Ospedali Galliera, 16128 Genoa, Italy.ORCID 0000-0003-3932-1330
Arnoldo PiccardoDepartment of Nuclear Medicine, Ente Ospedaliero Ospedali Galliera, 16128 Genoa, Italy.ORCID 0000-0002-6779-1471
Marco CuzzocreaDivision of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.ORCID 0000-0002-8214-562X
Gaetano PaoneDivision of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.ORCID 0000-0003-2864-5364
Giorgio TregliaDivision of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.ORCID 0000-0001-9808-780X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ActiniumNeuroendocrine TumorsOctreotideOrganometallic CompoundsRadiopharmaceuticalsHumansRadioisotopesTreatment OutcomeActiniumActinium-225OctreotideOrganometallic CompoundsRadioisotopesRadiopharmaceuticalsActinium-225alpha-emittingDOTATATEefficacymeta-analysisneuroendocrinenuclear medicineradioligand therapysafetysomatostatin

Identifiers

PMID40870386
PMCPMC12388371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.